Lipid Rafts and Cell Function

脂筏是富含胆固醇和鞘糖脂的膜微结构域。它们最初与脂质运输有关，但现在似乎参与了大量的生物过程，包括信号转导、内吞作用以及蛋白质和脂质分选。由于缺乏在完整细胞中分析脂筏的适当方法以及对其形成机制和细胞内生物学功能的了解不足，脂筏的研究受到了阻碍。本次会议将探讨与脂筏结构和功能相关的几个重要问题，包括：i)用于脂筏可视化和分析的生物物理和生化方法；Ii)木筏的生物发生及其大小；Iii)筏在信号转导中的作用；iv)筏在胞吞作用和蛋白质加工中的作用。

DESCRIPTION (provided by applicant) Lipid rafts are membrane microdomains that are enriched in cholesterol and glycosphingolipids. They were originally implicated in lipid trafficking, but now appear to be involved in a plethora of biological processes including signal transduction, endocytosis and protein and lipid sorting. Studies of lipid rafts have been hampered by the lack of appropriate methods to analyze them in intact cells and an insufficient understanding of their mechanism of formation and biological function within cells. This conference will examine several important issues related to the structure and function of lipid rafts including: i) biophysical and biochemical methods for the visualization and analysis of lipid rafts; ii) biogenesis of rafts and their size; iii) the role of rafts in signal transduction.; and, iv) the role of rafts in endocytosis and protein processing.