Cambridge ESRC DTP Interdisciplinary Studentship 2021: Early-life and intergenerational effects on later-life outcomes over the long-term

我提议的研究将探索两个主要主题，使用项目描述中提到的两个数据源。首先，我希望利用详细的德比郡健康访客记录来研究1918/1919年流感流行对妊娠期和出生后第一年婴儿的短期和长期影响。我想确定流感对孕妇和婴儿本身的一般影响，以及流感发作的时间如何影响其效果。我希望这项研究能增加关于子宫内电击的“积极选择”的争论。我还将使用数据集来研究婴儿死亡率和胎儿起源命题之间的关系。第二，我将使用剑桥集团的家庭重建数据集来研究英国的婴儿死亡率聚集，以及代际生育率和死亡率。通过这些想法，我希望扩大我们对婴儿死亡率在个体和人群中传播的机制以及子宫内环境如何受到外源因素影响的理解。我特别感兴趣的是健康不平等和婴儿死亡率背后的原因是如何随着时间的推移在生物学上表现出来的，以及如何打破这些循环。

My proposedresearch will explore two main themes, using the two data sources mentioned in the project description. Firstly, I hope touse the detailed Derbyshire Health Visitor records to study the short- and long-term impact of the 1918/1919 influenzaepidemic on infants during gestation and the first year of life. I want to identify the general impact of influenza on bothpregnant mothers and the infants themselves, and how the timing of the influenza-onset may have impacted its effect. Ihope this study can add to the 'positive selection' debate regarding shocks in utero. I will also use the dataset to look atthe relationship between infant mortality and the foetal origins thesis. Secondly, I will use the Cambridge Group FamilyReconstitution dataset to study infant mortality clustering in England, and intergenerational fertility and mortality rates.Through these ideas, I hope to expand our understanding of the mechanisms through which infant mortality ispropagated individually and across populations, and how in utero environments are impacted by exogenous factors. I amparticularly interested in how the causes behind health inequality and infant mortality manifest themselves biologicallyover time, and how to break these cycles.