The Variable Expression of CD33 on Leukemic Stem Cells

描述（由申请人提供）：这是一份申请K08奖的申请。候选人是密歇根大学医学中心血液和骨髓移植项目的初级教员。Becker博士的长期目标是成为白血病发生和干细胞生物学领域的独立实验室研究员。这份申请详细说明了一个四点计划，将为贝克尔博士提供必要的工具，以发展他的研究事业，使他能够实现这一目标。

DESCRIPTION (provided by applicant): This is an application for a K08 award. The candidate is a junior faculty member in the Blood and Marrow Transplantation Program at the University of Michigan Medical Center. Dr. Becker's long term goal is to become an independent laboratory investigator in the field of leukemogenesis and stem cell biology. This application details a four point program that will provide the necessary tools for Dr. Becker to develop his research career such that he can achieve this goal. First, Dr. Becker will obtain advanced conceptual and theoretical training in molecular biology and developmental biology with particular emphasis on carcinogenesis and stem cell biology by participating in several courses in the University of Michigan graduate school. Second, Dr. Becker will acquire additional research skills and techniques through the completion of his research project regarding the expression of CD33 on leukemic stem cells in Acute Myelogenous Leukemia. Dr. Becker has already achieved impressive preliminary data that have been submitted for publication in a leading peer reviewed journal. Third, Dr. Becker will acquire advanced communication skills, both written and oral, required for a successful career through participation in BMT research seminars and conferences, participation in national meetings and the preparation of manuscripts. Fourth, the applicant's progress throughout the award will be monitored by an advisory committee of senior researchers and academic leaders. The applicant's sponsor guarantees that 80% of Dr. Becker's effort will be devoted to his research for the period of this award.