FASEB Summer Conference on 'Autoimmunity'

这项续签提案要求部分支持美国实验生物学联合会(FASEB)2005年、2007年和2009年关于“自身免疫”的夏季会议，该会议通常每隔一年6月在佛蒙特州萨克斯顿河的佛蒙特学院举行。从历史上看，这次会议吸引了大约200名注册者(最高限额是在佛蒙特州举行)，并且每年与FASEB关于“淋巴细胞和抗体”的夏季会议交替举行。这次会议的目的是汇聚来自世界各地的来自学术界和制药行业的教授、博士后和博士后级别的基础顶级免疫学家和临床研究人员，分享在了解自身免疫性疾病的发病机制和调节方面的最新进展。自身免疫性疾病共同影响大约5%的人口，以每个主要器官系统为目标，因此是一个重大的健康问题。然而，目前对其病因尚不清楚，目前尚无治疗方法，有效的治疗方法也很少。 本次会议的目标是合并来自动物模型和患者研究的关于广泛的自身免疫性疾病的数据；分享T细胞和B细胞库的开发的最新进展；自我耐受性的建立和丧失的潜在机制；遗传和环境(传染性)触发因素对自身免疫性疾病的发生和进展的贡献；自身反应性T细胞向炎症部位的运输；组织损伤涉及的致病机制；以及调节自身免疫性疾病的最新治疗策略。这次会议的一大优势是非正式论坛，它将学生和研究员以及在这一与疾病高度相关且不断增长的领域中处于国际领先地位的知名研究人员聚集在一起。除了被邀请的发言者的口头陈述和其他与会者的海报陈述外，会议的形式允许从提交的摘要中选择两个简短的演讲(15分钟长) 在八次会议的每一次会议中穿插，为选定的研究生和博士后实习生提供了更正式的口头参与机会。一个主要目标是促进启动和加强该领域科学家之间的合作。这次会议是将基础和临床科学家聚集在一起的权威会议，他们的研究兴趣集中在自身免疫性疾病的病因学和发病机制上。

This renewal proposal requests partial support for the 2005, 2007 and 2009 meetings of the Federation of American Societies of Experimental Biology (FASEB) Summer Conference on 'Autoimmunity' which is normally held every other June at the Vermont Academy in Saxtons River, VT. Historically, this meeting has been fully subscribed attracting approximately 200 registrants (the upper limit accommodated at the Vermont venue) and alternates years with the FASEB Summer Conference on 'Lymphocytes and Antibodies'. The purpose of the conference is to bring together basic top immunologists and clinical researchers from academia and the pharmaceutical industry at the professorial, post-doctoral and pre-doctoral levels from around the world to share the latest advancements in understanding of the pathogenesis and regulation of autoimmune disease. Autoimmune diseases together affect approximately 5% of the population targeting every major organ system and thus represent a significant health problem. However, there is not yet clear understanding of their etiologies and at present there are no cures and few useful therapies. The goal of this meeting is to merge data from animal models and patient studies on a broad range of autoimmune diseases; to share recent advances on the development of the T cell and B cell repertoires; mechanisms underlying the establishment and loss of self tolerance; the contribution of genetic and environmental (infectious) triggers to autoimmune disease development and progression; trafficking of autoreactive T cells to sites of inflammation; the pathogenetic mechanisms involved in tissue injury; and the latest therapeutic strategies for regulating autoimmune diseases. A major strength of the meeting is the informal forum that brings students and fellows together with established investigators who are international leaders in this highly disease-relevant and continually growing field. In addition to the oral presentations of the invited speakers and poster presentations by other attendees, the format of the meeting allows two short talks (15 minutes in length), selected from among the submitted abstracts, to be interspersed into each of the eight sessions providing the opportunity for more formalized oral participation by selected graduate student and postdoctoral trainees. A major goal is to foster the initiation and strengthening of collaborations among scientists in the field. This conference serves as the definitive meeting for bringing together basic and clinical scientists with research interests focusing on the etiology and reaulation of autoimmune diseases.