C-H Bond Activation in Synthesis of Organic Molecules

描述：(申请者描述)计划的重点是 通过C-H键活化合成复杂天然产物。这种可能性 在复杂的背景下这些转变的位置选择性 底物具有很大的合成潜力。假设这样的目标是 实现了新颖而独特的天然分子组装合成策略 产品是可以预见的。该计划将侧重于开发 用于定向C-H活化的过渡金属试剂和催化剂。 C-H活化反应的选择性将通过使用 合适的杂原子/官能团(大多数情况下为亚胺基团)以激活和 将金属络合物直接引入双烷基团。遵循这一逻辑，新的 第四纪立体中心的方法将在三个背景下进行探索 天然产物类别(天冬青生物碱、刺青素生物碱和 精选的萜类衍生天然产品)。

DESCRIPTION: (Applicant's Description) The proposed program focuses on synthesis of complex natural products via C-H bond activation. The possibility of site selectivity of these transformations in the context of complex substrates is of significant synthetic potential. Assuming such goals were realized novel and unique synthetic strategies for the assembly of natural products can be envisioned. This program will focus on development of transition metal reagents and catalysts for directed C-H activation. Selectivity of C-H activation reactions will be achieved through the use of a suitable heteroatom/functionality (imine group in most cases) to activate and direct metal complexes to geminal dialkyl groups. Following this logic, new ways to quaternary stereogenic centers will be explored in the context of three classes of natural products (aspidosperma alkaloids, teleocidin alkaloids and selected terpene-derived natural products).