Health - Determining the effect of Salmonella infection on longlived intestinal macrophages and identifying their role in preventing IBD

沙门氏菌是一种全球性的重要肠道感染，每年导致约9380万例肠胃炎病例。虽然通常是一种自限性疾病，但沙门氏菌感染可导致炎症性肠病（IBD）和结肠癌的风险增加。这些感染后问题的原因尚不完全清楚，进一步的了解可能会导致恢复性治疗的发展，以防止这些不良后果。巨噬细胞在维持胃肠道健康、维持粘膜屏障完整性和控制该部位炎症方面发挥着关键作用；这些功能失调也与IBD和结肠癌有关。

Salmonella is a globally significant intestinal infection, causing an estimated 93.8 million cases of gastroenteritis per year. Although usually a self-limiting disease, Salmonella infection can result in increased risk of inflammatory bowel disease (IBD) and colon cancer. The reasons for these post-infection problems are not fully known and further understanding may lead to the development of restorative therapies to prevent these adverse outcomes. Macrophages are known to play a critical role in maintaining gastrointestinal health, contributing to maintaining mucosal barrier integrity and controlling inflammation at this site; dysregulation of these functions are also linked to IBD and colon cancer.