Understanding and Exploiting Drug Reactivity with Lipid Membranes.

最近有一件事变得很明显，那就是脂质会对药物的隔膜起反应。该项目的目标是了解生物膜中这种反应性的程度、性质和后果，并设计药物来利用这种反应性以穿越膜屏障。实现这一目标的策略包括合成可被细胞吸收并并入膜脂中的脂肪酸，以实现对修饰药物的纯化和检测，在相关细胞系中筛选这些脂类，以及合成修饰药物以诱导可检测的反应性。合成脂肪酸也将被合并到脂类中，这些脂类的特征是作为模型膜系统的脂质体。

It has recently become apparent that lipids are reactive towards drugs that partition into membranes. The goals of this project are to understand the extent nature and consequences of this reactivity in biological membranes, and to engineer drugs to exploit this reactivity in order to traverse membrane barriers. The strategies for achieving this is include the synthesis of fatty acids that can taken up into cells and incorporated into membrane lipids to enable the purification and detection of modified drugs, screening of these lipids in relevant cell lines, and the synthesis of modified drugs to induce detectable reactivity. Synthetic fatty acids will also be incorporated into lipids and these lipids characterised in liposomes as model membrane systems.