ANXIETY, DEPRESSION AND ASTHMA IN PUERTO RICAN YOUTH

描述(申请人提供)：本申请响应NIMH计划公告(PA)02-047，共病精神和其他身体障碍研究。文献中描述了儿童和青少年精神和心理问题与父母对哮喘的报告之间的联系，有一些证据表明，哮喘及其与精神障碍的联系在波多黎各青年中尤其令人震惊。然而，以前研究的方法论设计在很大程度上局限于使用临床样本、横断面研究，以及使用非标准化或以其他方式折衷的青少年精神障碍或哮喘测量。这些限制阻碍了对社区中的协会的解释。这项拟议的研究克服了许多这些限制，将在波多黎各青年中确定焦虑和抑郁障碍与哮喘之间的联系程度，并将在儿童和青少年样本中确定照顾者的精神障碍与哮喘风险之间的联系。此外，它还将确定照料者的精神病理、应激源、功能和儿童哮喘管理之间的预期关系。这项研究建立在之前收集的两波波多黎各青年(R01-MH054827；Glorisa Canino博士)1999年至2001年的数据基础上。它将从最初的队列中分层抽样700名青年，收集关于儿童/青少年和照顾者精神障碍、哮喘患病率和严重程度以及心理社会问题的新的第三波数据。我们还将从700名受试者中分层抽取200人进行肺活量测试和病历审查。这项拟议的研究将使我们能够开始调查哮喘和精神障碍共病的机制和临床管理后果。总体而言，这项研究将提供关于拉美裔青年的两个主要公共卫生问题--精神健康和哮喘--的有用信息，并开始调查这两个关键公共卫生问题之间的联系。

DESCRIPTION (provided by applicant): This application responds to NIMH Program Announcement (PA) 02-047, Research on Co-Morbid Mental and Other Physical Disorders. Associations between child and adolescent psychiatric and psychological problems and parent reports of asthma have been described in the literature, and there is some evidence that the prevalence of asthma and its association with mental disorders is particularly striking in Puerto Rican youth. However, the methodological designs of previous studies have been largely limited to the use of clinical samples, cross-sectional studies, and the use of non-standardized or otherwise compromised measures of psychiatric disorders or asthma in youth. These limitations prevent interpretation of the associations in the community. The proposed study overcomes many of these limitations and would establish the magnitude of associations between anxiety and depressive disorders and asthma in Puerto Rican youth, and it would also determine the associations between caregivers' mental disorders and risk for asthma in the sample of children and adolescents. Further, it would determine the prospective relations between caregiver psychopathology, stressors, functioning and the management of childhood asthma. The study builds on two previously collected waves of data of Puerto Rican youth (R01-MH054827; Dr. Glorisa Canino), from 1999-2001. It would collect a new, third wave of data on child/adolescent and caregiver psychiatric disorders, asthma prevalence and severity, and psychosocial problems in a stratified sample of 700 youth from the original cohort. We will also take a stratified sample of 200 of the 700 subjects for spirometry testing and medical chart review. The proposed study will allow us to begin to investigate the mechanisms and clinical management consequences of co-morbid asthma and mental disorders. Overall, this study will provide useful information on two major public health problems for Hispanic youth, mental health and asthma, and begin to investigate the links between theses two critical public health issues.