A San Francisco Street Youth Cohort: At Risk and HIV+

描述(由申请者提供)：这是旧金山青少年医学试验中心的重新竞赛申请，这是加州大学旧金山分校(UCSF)和拉金街青年服务中心(Lsys)的合作项目。旧金山的目标是RFA中概述的关键弱势群体：离家出走的无家可归者、滥用药物和少数族裔青年以及变性人青年。我们的目标仍然是继续接触感染艾滋病毒和未感染艾滋病毒的处于危险中的弱势青年，并让他们安全地参与临床和行为研究。我们的目标是继续为未来进行艾滋病毒疫苗试验创造一个强大的基础设施。我们相信，我们为ATM的整体实力和广度做出了贡献，并满足了对更新的期望。我们的网站是一个以社区为中心的ATU，而不是大学；将大学的专业知识合作带到社区。我们的艾滋病毒阳性青少年的主要临床人口在拉金街青年服务(Lsys)社区诊所接受医疗护理，我们现在已经聘请了14个以上的社区站点招募和转介参加ATN研究。截至2005年3月1日，我们已经招募了77名受试者加入我们网站目前开放的临床和预防方案(021,022、023B、024、025和0168)，参加了几个方案开发团队(015、016B、034、039和PACTG 1046)，我们的一名员工是完成关于连接到保护的第一篇论文的主要作者。加州大学旧金山分校青春期医学分部为青少年医学研究和临床服务提供了丰富的资源。SF团队的ATU包括PI、Moscicki博士、我们的连接到保护(C2P)团队成员Catherine Geanuracos、LCSW、Kevin Sniecinski和Colette Auerswald博士、研究协调员Bathany Certa、RN、BSN和J.B.Molaghan ANP-C，以及工作人员助理Nigel Reyes。在Lsys，医学博士Alan Taggart在拉金街青年中心为感染艾滋病毒和未感染艾滋病毒的青年提供服务已有九年多。他和外展工作人员希瑟·韦斯布罗德有效地识别、筛选和招募无家可归的青年参加试验。我们的诊所服务包括Lsys，它有一个全面的、以年轻人为中心的、适合文化的艾滋病毒护理模式，以及加州大学旧金山分校的积极健康实践和儿科艾滋病计划。总而言之，我们的ATU网站是大学和社区之间独特的合作伙伴关系。在过去的5年里，我们巩固了我们的承诺，确保边缘化和弱势青年参与研究的权利。连接到保护项目扩大了我们与社区的参与，并将更多的机构纳入我们的转介网络。我们认为，继续让旧金山湾区的高危青年参与临床和行为研究是至关重要的。

DESCRIPTION (provided by applicant): This is an application for the re-competition of the Adolescent Medicine Trials Unit in San Francisco, a collaboration between the University of California San Francisco (UCSF) and Larkin Street Youth services (LSYS). San Francisco targets the key vulnerable populations outlined in the RFA: runaway homeless, substance abusing and minority youth, as well as transgender youth. Our aims remain to continue outreach to vulnerable youth both HIV infected and uninfected at risk and to engage them safely in clinical and behavioral research. We aim to continue creating a strong infrastructure for performing HIV vaccine trials in the future. We believe we contributed to the overall strength and breadth of the ATM and meet the expectations for renewal. Our site is an ATU centered in the community rather than the university; bringing university expertise in partnership to the community. Our primary clinical population of HIV positive youth receives medical care at Larkin Street Youth Services' (LSYS) community clinic, and we now have engaged more than 14 other community sites in recruitment and referrals into ATN studies. As of March 1, 2005 we have recruited 77 subjects into currently open clinical and prevention protocols at our site (021,022, 023B,024, 025, and 0168), have participated in several protocol development teams (015, 016B, 034, 039 and PACTG 1046), and a member of our staff was lead author on the first paper to be completed about Connect to Protect. UCSF Division of Adolescent Medicine is a rich resource for adolescent medicine research and clinical services to youth. The ATU at SF team includes the PI, Dr. Moscicki, our Connect to Protect (C2P)team members Catherine Geanuracos, LCSW, Kevin Sniecinski, and Dr. Colette Auerswald, Study Coordinators Bethany Certa, RN, BSN and J.B. Molaghan ANP-C, and staff assistant Nigel Reyes. At LSYS, Alan Taggart, M.D., has served HIV infected and uninfected youth at Larkin Street Youth for over nine years. He and Heather Weisbrod, the outreach worker, have effectively identified, screened and recruited homeless youth into trials. Our clinic services include LSYS, which has a comprehensive, youth centered, culturally appropriate model of HIV care, and, at UCSF, the Positive Health Practices and Pediatrics AIDS Program. In summary, our ATU site is a unique partnership between the university and the community. During the last 5 years, we have solidified our commitment to ensure marginalized and vulnerable youths' right to participate in research. The Connect to Protect project has expanded our involvement with the community and has brought additional agencies into our referral network. We believe it is critical to continue to engage the high risk youth in the San Francisco Bay Area in clinical and behavioral research.