The role of R-loops in trinucleotide expansion diseases

r环是一种核酸结构，由RNA/DNA杂交和移位的单链DNA组成。r -环具有一系列生理作用，也与人类病理有关。该项目旨在进一步揭示支持r -环相关疾病的分子机制。将特别关注弗里德赖希共济失调，作为三核苷酸扩张疾病的模型。了解弗里德赖希共济失调中R-loop功能背后的机制将为开发新的治疗方法铺平道路。

R-loops are nucleic acid structures, composed of an RNA/DNA hybrid and displaced single-stranded DNA. With an array of physiological roles, R-loops have also been implicated in human pathologies. This project aims to further uncover the molecular mechanisms that underpin R-loop-associated diseases. There will be a particular focus on Friedreich's ataxia, as a model of trinucleotide expansion diseases. Understanding the mechanisms behind R-loop function in Friedreich's ataxia will pave the way for the development of new therapeutic approaches for this group of disorders.