A Novel Therapeutics for Pandemic & Epidemic Flu

描述（由申请人提供）：为了解决流感大流行问题，迫切需要广谱流感疗法，这是对全球公共卫生的主要威胁。我们提出的研究旨在产生一类新的融合蛋白，能够阻断所有流感病毒株的感染。具体来说，融合蛋白由蛋白酶抑制剂和锚定结构域组成，蛋白酶抑制剂抑制所有流感病毒的激活，锚定结构域有助于丰富药物并延长药物在呼吸上皮上的滞留时间。在拟建的I期研究中，我们将生成该蛋白酶抑制剂及其融合蛋白，比较其体外功能活性，选择最佳构建物进行II期研究。

DESCRIPTION (provided by applicant): Broad-spectrum therapeutics for influenza are critically needed to address the problem of influenza pandemics, a major threat to the public health globally. We have proposed studies that aim at generating a novel class of fusion proteins capable of blocking infections by all strains of influenza viruses. Specifically, the fusion protein is composed of a protease inhibitor that inhibits activation of all influenza viruses and an anchoring domain that helps to enrich the drug and prolong the drug retention on the respiratory epithelium. In the proposed phase I study, we will generate this proteinase inhibitor and its fusion proteins, compare their functional activities in vitro and choose the best construct for phase II study.