Identifying Broad-Spectrum Influenza Virus Inhibitors

描述(申请人提供)：迫切需要对流感进行广谱治疗，以解决流感大流行的问题，流感大流行是全球公共卫生的主要威胁。我们提出的研究旨在通过针对宿主因素来识别能够阻止所有流感病毒株感染的分子，宿主因素是激活所有流感病毒所必需的。在这项拟议的第一阶段研究中，我们将产生候选药物，表征并比较它们的体外生化和功能活性。我们的目标是确定两个最终候选者，并为第二阶段研究中的进一步临床前评估做好准备。

DESCRIPTION (provided by applicant): Broad-spectrum therapeutics for influenza is critically needed to address the problem of influenza pandemics, a major threat to the public health globally. We have proposed studies aiming at identifying molecules that are capable of blocking infections of all strains of influenza viruses by targeting the host factors which are essential for activation of all influenza viruses. In this proposed phase I study, we will generate the drug candidates, charactering and compare their biochemical and functional activities in vitro. Our goal is to have two final candidates identified and ready for further preclinical evaluation in phase II study.