Ohio State Neuroscience Center Core

描述(由申请人提供)： 通过使用模型遗传有机体，已经收集到了对人类神经疾病的关键见解。NINDS中心核心提案的主要目的是加强研究人员对俄亥俄州立大学各种动物模型系统的访问。已经确定了16名有资格的调查人员，他们构成了拟议中的俄亥俄州NINDS神经科学中心。这个小组不仅汇集了动物和转基因模型研究大脑发育、功能、疾病和损伤的共同需求，而且还汇集了各种协同专业知识。还确定了一个广泛的中心用户基础(非合格的NINDS赠款持有人)。该中心核心建议的目的有几个方面：支持目前由NINDS资助的研究人员，促进这些研究人员之间的互动项目，为俄亥俄州立大学校园内由NINDS资助的其他核心用户提供支持，并促进整个大学基础研究人员和翻译研究人员之间的互动。需要一个遗传学核心以及啮齿动物行为、电生理学和共焦显微镜核心。组成该中心的合格项目包括脊髓损伤和再生、生长锥体指导、大分子的轴突和树突运动、亨廷顿病兴奋毒性的机制、脊髓性肌萎缩症的遗传学、实验性中风结果和康复等。在NINDS资助的用户群中，将使用动物和转基因模型的其他项目包括细胞周期控制机制、皮层ACh定向注意控制机制以及病毒性脑炎的细胞应激反应。

DESCRIPTION (provided by applicant): Key insights into human neurological disorders have been gleaned through the use of model genetic organisms. The main purpose of this NINDS Center Core proposal is to enhance investigator access to a variety of animal model systems at Ohio State. Sixteen qualifying investigators have been identified that constitute the proposed Ohio State NINDS Neuroscience Center. This group brings together not only a common need for animal and transgenic models to study brain development, function, disease, and injury, but also a diverse spectrum of synergistic expertise. A broad base of Center users (non-qualifying NINDS grant holders) has also been identified. The aims of this Center Core proposal are several fold: to support current NINDS-funded investigators, to facilitate interactive projects amongst these investigators, to provide support for other NINDS-funded Core users around the Ohio State campus, and to facilitate interactions amongst basic and translational researchers throughout the University. A Genetics Core as well as Rodent Behavior, Electrophysiology, and Confocal Microscopy Cores are requested. Qualifying projects that make up the Center include spinal cord injury and regeneration, growth cone guidance, axonal and dendritic movements of macromolecules, mechanisms of Huntington's disease excitotoxicity, the genetics of spinal muscular atrophy, experimental stroke outcome and recovery, and many more. Additional projects in the NINDS-funded user base that would employ animal and transgenic models include mechanisms of cell cycle control, mechanisms of cortical ACh-directed attentional control, and the cellular stress response in viral encephalitis.