Medical Physics Training Grant for Image-Guided Therapy Research

描述（由申请人提供）：每年有超过一百万的美国居民被诊断患有癌症。需要先进的成像程序来更准确地定义和非侵入性地表征肿瘤病变。显然需要图像引导治疗，包括用于外部射束适形放射治疗（立体定向或强度调制）以及用于密封和非密封源放射治疗的图像引导治疗计划，以最佳地治疗每个个体患者。此外，继续有一个显着增加的使用图像引导的直接介入程序（介入放射学或手术），以改善预后结果和患者的生活质量后的干预。为了改善肿瘤过程的药理学治疗，使用分子成像核医学方法或磁共振成像的先进生理成像技术正在用于评估新型细胞毒性和/或细胞生长抑制剂的疗效，其时间比当前病变大小变化标准（如RECIST）允许的时间早得多。最后，需要这种生理成像技术，以便在细胞生长抑制剂的临床试验中建立最佳生物剂量，而不是最大耐受剂量，例如，抗血管生成/抗血管药物。由于所有这些原因，显然需要培训和发展具有图像引导治疗专业知识的独立科学家。此外，迫切需要在图像引导放射治疗方面接受过必要培训的临床医学物理学家，因为已经有充分证据证明缺乏这样的人。为了满足对这些训练有素的个人的压倒性需求，目前只有11个医学物理学研究生课程获得医学物理学研究生课程认证委员会（CAMPEP）的认证，其中只有8个课程在美国。并且还可以具有相关的博士后教育计划，用于培训个人在医学物理学或相关领域的研究事业。然而，培训机会的任何增长都迅速超过了对在图像引导治疗方面具有扎实的跨学科临床和研究培训的个人的迫切需求。 拟议的新培训计划的主要目标是培养独立的研究科学家和临床医学物理学家，并在先进的生理成像技术和图像引导治疗方面进行必要的培训。培训补助金的可用性将使我们的CAMPEP认证的医学物理学研究生教育计划，通常被列为北美顶级计划之一，以扩大该领域的学员数量，并为医学物理学家和成像专家的培训提供独特的环境，这些医学物理学家和成像专家具有当前迫切需要的跨学科经验，特别是在未来的环境中。

DESCRIPTION (provided by applicant): More than one million U.S. inhabitants are diagnosed with cancer each year. Advanced imaging procedures are needed to more accurately define and non-invasively characterize neoplastic lesions. Image-guided therapies, including image-guided treatment planning for external beam conformal radiation therapy (stereotactic or intensity modulated) and for sealed and unsealed source radiation therapy, are clearly needed to optimally treat each individual patient. In addition, there continues to be a dramatic increase in the use of image-guided direct interventional procedures (interventional radiology or surgery) to improve both the prognostic outcome and the patient's quality of life following the intervention. In order to improve the pharmacological treatment of neoplastic processes, advanced physiological imaging techniques, using molecular imaging nuclear medicine approaches or magnetic resonance imaging, are being used to assess the efficacy of novel cytotoxic and/or cytostatic agents much earlier than current lesion size change criteria, such as RECIST, allow. Finally, a need has developed for such physiological imaging techniques to order to establish optimal biologic dose, rather than maximum tolerated dose, in clinical trials of cytostatic agents, e.g., antiangiogenic/antivascular drugs. For all of these reasons, a clear need exists for the training and development of independent scientists with expertise in image-guided therapy. In addition, clinical medical physicists with the necessary training in image-guided radiation therapy are sorely needed, as there is already a well-documented shortage of such individuals. To address the overwhelming need for such well trained individuals, only 11 graduate programs in medical physics are presently accredited by the Commission on Accreditation of Graduate Programs in Medical Physics (CAMPEP), and only 8 of those programs are in the U.S. These programs support the training and development of pre-doctoral medical physics trainees, and may also have associated post-doctoral education programs for training individuals for research careers in medical physics or related fields. However, any growth in training opportunities is being rapidly outpaced by the urgent need for individuals with solid interdisciplinary clinical and research training in image guided therapies. The primary goal of the proposed new training program is the development of independent research scientists and clinical medical physicists with the necessary training in advanced physiological imaging techniques and image-guided therapy. The availability of training grant funds would allow our CAMPEP-accredited Medical Physics Graduate Education Program, commonly ranked as one of the top programs in North America, to expand the number of trainees available to the field and to provide a unique environment for the training of medical physicists and imaging specialists with the interdisciplinary experience that is sorely needed in the current, and particularly in the future environment.