Training in Biologic Threat Agents

描述(申请人提供)：公共卫生措施已经成功地减少了由于许多高致病性病原体引起的疾病的发病率，但很明显，我们很容易受到故意将感染性病原体引入环境的影响。这笔培训赠款将利用以下重点领域的研究优势：发病机制、毒素生物学、疫苗研究和感染和免疫的动物模型、肺部生物学、传染病和宿主反应、蛋白质组学/基因组学/基因阵列以及快速检测和环境工程。艾莉森·韦斯博士将担任主任，乔治·迪普博士将担任这项培训赠款的联席主任。来自辛辛那提大学医学院、工程学院和化学系的高才华和互动的研究人员，以及附属于儿童医院医学中心和退伍军人管理医学中心的加州大学教职员工将加入他们的行列。培训人员包括：21名教授、8名副教授和6名助理教授。培训人员可以获得令人印象深刻的外部资金。博士后和博士后实习生将获得为期两年的支持。他们将从辛辛那提大学录取的对生物恐怖主义研究感兴趣的个人中招募，并致力于与一名培训补助金教员合作。MD实习生将得到为期三年的支持，并将被招募为他们的住院医师或研究员培训计划的一部分，其中包括次级专业临床培训。第一年招收两名博士前研究生，此后每年新增三名实习生。第一年将招收两名博士后实习生，此后每年增加一名实习生。对于MD博士后实习生，我们将在第一年接受一名个人，并在接下来的几年中每年增加一名。辛辛那提大学医疗综合体的特殊资源包括：全新的、最先进的P3生物遏制设施、蛋白质组学设施、DNA核心实验室、最先进的核磁共振设施、即将上线的X射线结晶学设施，以及由美国国立卫生研究院资助的儿童医院疫苗检测单位。

DESCRIPTION (provided by applicant): Public health measures have successfully reduced the incidence of disease due to many highly pathogenic agents, but it has become clear that we are vulnerable to deliberate introduction of infectious agents into the environment. This training grant will draw on research strengths in the following focus areas: Pathogenesis, Toxin Biology, Vaccine Studies and Animal Models of Infection and Immunity, Pulmonary Biology, Infectious Diseases and Host Response, Proteomics/Genomics/Gene Arrays, and Rapid Detection and Environmental Engineering. Dr. Alison Weiss will serve as Director, and Dr. George Deepe will serve as Co-Director of this training grant. They will be joined by highly talented and interactive researchers from the University of Cincinnati College of Medicine, College of Engineering, and the Department of Chemistry, as well as UC faculty affiliated with the Children's Hospital Medical Center and the Veteran's Administration Medical Center. The training faculty includes: 21 Professors, eight Associate and six Assistant Professors. An impressive level of external funding is available to the training faculty. Pre- and Postdoctoral PhD trainees will be supported for two years. They will be recruited from individuals admitted to the University of Cincinnati who are interested in bioterrorism research, and committed to working with a training grant faculty member. The MD trainees will be supported for three years, and will be recruited as part of their resident or fellowship-training program, which includes sub-specialty clinical training. Two predoctoral students will be enrolled the first year, with three new trainees added each year thereafter. Two PhD postdoctoral trainees will be enrolled in first year, with one new trainee added each year thereafter. For MD postdoctoral trainees, we will accept one individual the first year and one additional individual in each of the following years. Special resources at the University of Cincinnati Medical Complex include: a brand-new, state-of-the-art P3 Bio-containment facility, proteomics facility, DNA core lab, state-of-the-art NMR facility, X-ray crystallography facility to come on line, and an NIH funded Vaccine Testing Unit centered at Children's Hospital.