INTEGRATIVE IMMUNOLOGY TRAINING PROGRAM

描述（由申请人提供）：U.T.综合免疫学培训计划的目的。西南大学为现代免疫学研究的博士前和博士后研究员提供全面的培训。目标是培养出训练有素的科学家，他们能够开发研究项目，以研究正常的免疫系统功能和导致人类疾病的免疫系统功能缺陷。 这一目标是通过培训活动的综合组合来实现的，其中包括细胞和分子免疫学，免疫系统的遗传操纵，肿瘤免疫学和生物信息学的正式高级课程，研究奖学金提案开发和资格考试形式的口头答辩，定期工作进展研讨会，教学机会，职业发展计划和跨学科实验室研究。该培训计划围绕免疫学研究生课程，在细胞和分子生物学在德州大学的部门的八个研究生课程之一。西南部培训计划包括来自校园内几个部门/部门的32名教师，包括免疫学，微生物学，病理学，癌症免疫学，流变学，神经病学，内科学，皮肤病学和眼科学。参与实验室开展的研究项目包括：系统性红斑狼疮、多发性硬化症和类风湿性关节炎等自身免疫性疾病的细胞、分子和遗传决定因素的研究;自然杀伤细胞激活和杀伤机制;抗原加工和呈递的复杂性;肿瘤细胞归巢和迁移机制;体外和体内肿瘤细胞生长的调节;正常淋巴细胞发育和迁移的调节;正常和恶性淋巴细胞中的信号转导;对HIV和其他感染因子的免疫应答;以及抗肿瘤免疫毒素的开发。该培训计划的基本原理反映了对接受免疫学培训的研究科学家的需求，因为免疫系统在各种人类疾病和临床情况中起着积极和消极的作用，包括癌症预防和治疗，器官移植，自身免疫，免疫缺陷和传染病。通过此次提交，该培训计划进入了其卓越培训的第27个年头。我们以前的学员已经离开该计划与强大的出版物记录在学术界和工业界优秀的研究职位。我们的许多教师和以前的学员担任的领导职务反映了所提供的培训计划的高质量。 参与教师：培训教师32人，其中教授14人，副教授6人，助教9人。10名培训教员是妇女。所有的教师都在德克萨斯大学西南分校。

DESCRIPTION (provided by applicant): The purpose of the Integrative Immunology Training Program at U.T. Southwestern is to provide comprehensive training of pre-doctoral and postdoctoral fellows in the conduct of modem immunology research. The goal is to produce sophisticated and highly trained scientists who are capable of developing research programs to investigate normal immune system function and the defects in immune system function that contribute to human disease. This goal is achieved through an integrated combination of training activities that includes formal advanced coursework in Cellular and Molecular Immunology, Genetic Manipulation of the Immune System, Tumor Immunology and Bioinformatics, research fellowship proposal development and oral defense in the form of a Qualifying Exam, regular Works-in-Progress seminars, teaching opportunities, career development programs and interdisciplinary laboratory research. The training program revolves around the Immunology Graduate Program, one of the eight graduate programs in the Division of Cellular and Molecular Biology at U.T. Southwestern. The training program includes thirty-two faculty from several departments/divisions on campus, including Immunology, Microbiology, Pathology, Cancer Immunology, Rheumatology, Neurology, Internal Medicine, Dermatology and Ophthalmology. Research projects pursued in the participating laboratories include investigations of the cellular, molecular and genetic determinants of the autoimmune diseases systemic lupus erythematosis, multiple sclerosis and rheumatoid arthritis; mechanisms of natural killer cell activation and killing; complexities of antigen processing and presentation; mechanisms of tumor cell homing and migration; regulation of tumor cell growth in vitro and in vivo; regulation of normal lymphocyte development and migration; signal transduction in normal and malignant lymphocytes; immune response to HIV and other infectious agents; and development of anti-tumor immunotoxins. The rationale for this training program reflects the need for research scientists with training in immunology given that the immune system plays both positive and negative roles in a variety of human diseases and clinical situations, including cancer prevention and treatment, organ transplantation, autoimmunity, immunodeficiency and infectious disease. With this submission, this training program enters its 27th year of training excellence. Our previous trainees have left the program with strong publications records to excellent research positions in academia and industry. The leadership positions held by many of our faculty and previous trainees reflect the high quality of the training program provided. PARTICIPATING FACULTY: The 32 training faculty include 14 professors, 6 associate professors, and 9 assistant professors. 10 of the training faculty are women. All of the faculty are at the University of Texas Southwestern.