Fast iZQC for High Resolution MRS In Vivo

描述（由申请人提供）：本提案描述了一种从以前无法获得的器官中获取高分辨率磁共振光谱的方法。在大多数器官中，不均匀性使得化学成分的峰分配困难和虚假，但分子间零量子相干（izqc）对不均匀性不敏感。izqc的独特之处在于它们在非均质样品（如人体组织）中提供非常高的分辨率光谱。然而，在体内的分辨率增强已被证明是难以捉摸的。我们的结果表明，这是由于在相对缓慢的iZQC信号采集过程中的生理波动。这促使我们开发一种新的快速获取izqc的方法，这将使我们能够取许多平均值来消除这些生理波动的变幻莫测。我们展示了这个序列，以及在高达31倍加速的幻影上获得的初步结果。该提案概述了我们的方法，以取得更快的进展和其他改进，如水抑制，这将使我们能够将其发展成为一种强大的体内技术。

DESCRIPTION (provided by applicant): This proposal describes a method to acquire high resolution magnetic resonance spectra from previously inaccessible organs. In most organs, inhomogeneity makes the assignment of peaks to chemical components difficult and spurious, but intermolecular zero quantum coherences (iZQCs) are insensitive to inhomogeneity. iZQCs are unique in that they give very high resolution spectra in inhomogenous samples, such as human tissue. Resolution enhancement in vivo, however, has proven elusive. Our results indicate that this is due to physiological fluctuations during the relatively slow acquisition of the iZQC signal. This has motivated us to develop a new fast acquisition method for iZQCs which will allow us to take many averages to mute the vagaries of these physiological fluctuations. We present this sequence, along with preliminary results acquired on phantoms for up to 31-fold speedup. This proposal outlines our method for progressing to still faster acquisitions and other improvements, such as water suppression, that will allow us to develop this into a robust technique in vivo.