Contextual Determinants of HIV/STI Sexual Transmission

描述(由申请人提供)： 使用加利福尼亚州旧金山非裔美国人城市青少年的性网络研究和美国人口普查的数据，该应用程序将是第一批评估个人因素、网络特征和邻里社会经济背景如何结合在一起创造艾滋病毒和性传播感染风险的应用程序之一。鉴于个人层面的因素无法充分解释这一群体的疾病风险，理解为什么生活在资源匮乏社区的少数群体青少年容易受到性传播感染，这一点尤为重要。本研究的目的是：1)确定与个人层面的性传播感染风险相关的性网络特征，控制个人层面的人口和行为风险因素；2)确定与个人层面的性传播感染风险相关的社区层面的社会经济特征；3)确定网络和个人层面的特征是否在社区层面的社会经济背景和个人层面的疾病风险之间起中介作用。确定个人、网络和社区各级的风险因素将为制定下一代多层次干预措施提供必要的目标，以预防弱势社区的艾滋病毒和其他性传播感染。

DESCRIPTION (provided by applicant): Using data from a study of the sexual networks of African American urban adolescents in San Francisco, CA, and from the US Census, this application will be one of the first to assess how individual factors, network characteristics, and neighborhood socioeconomic context combine to create HIV and STI risk. It is particularly important to understand why minority adolescents living in resource-poor communities are vulnerable to STIs in the light of the inability of individual-level factors to fully explain disease risk in this population. This study aims 1) to identify sexual networks features that are associated with individual-level STI risk, controlling for individual-level demographic and behavioral risk factors, 2) to identify neighborhood level socioeconomic characteristics that are associated with individual-level STI risk, and 3) to determine if network- and individual-level characteristics mediate the relationship between neighborhood-level socioeconomic context and individual-level disease risk. Identification of risk factors at the individual, network and community levels will provide the targets necessary for the development of the next generation of multilevel interventions to prevent HIV and other STIs in disadvantaged communities.