Developmental Research Program

芝加哥大学乳腺癌孢子发育研究计划的目标 (DRP)是建立一个精简和透明的机制，征集和遴选令人兴奋的 具有显著翻译成功潜力的新奇研究项目。这类项目可能是 我们孢子内的科学家之间的合作，或者孢子外的合作 环境，但必须是创新的，潜在的高影响，最好是多学科的。这 该计划将由杰弗里·格林博士领导，他是雌激素受体领域的领导者，对此有浓厚的兴趣 在将基础科学转化为临床乳腺癌方面，以及苏珊娜·康岑博士，一位内科科学家和 专攻乳腺癌的医学肿瘤学家，其实验室使用大规模基因组方法 寻找促进乳腺上皮细胞转化的新的抗细胞凋亡信号通路 细胞。具体地说，孢子DRP将1)建立征集DRP申请的机制，该机制 从癌症中心成员和当地孢子社区扩展到所有生物，物理， 芝加哥大学和阿贡国立大学的计算机和社会科学教员 实验室，以及全国其他孢子的调查人员；2)鼓励、支持和培育 利用我们跨学科内部科学咨询的专业知识进行跨学科协作 委员会；3)选择和评估有助于为发展产生新假设的项目 孢子项目。

The objective of the University of Chicago Breast Cancer SPORE Developmental Research Program (DRP) is to create a streamlined and transparent mechanism for soliciting and selecting exciting and novel research projects that have significant potential for translational success. Such projects may be collaborative among scientists within our SPORE, or have collaborations outside the SPORE environment, but must be innovative, potentially high impact, and preferably multi-disciplinary. This program will be led by Dr. Geoffrey Greene, a leader in the estrogen receptor field with a strong interest in translating basic science to clinical breast cancer, and Dr. Suzanne Conzen, a physician-scientist and medical oncologist specializing in breast cancer whose laboratory uses large scale genomic approaches to identify novel anti-apoptotic signaling pathways contributing to the transformation of breast epithelial cells. Specifically, the SPORE DRP will 1) establish a mechanism for soliciting DRP applications that reaches beyond cancer center members and the local SPORE community to all biological, physical, computer and social science faculty members at the University of Chicago and Argonne National Laboratory, as well as to investigators at other SPOREs nationwide; 2) encourage, support, and nurture interdisciplinary collaboration using the expertise of our interdisciplinary Internal Scientific Advisory Committee; 3) select and assess projects that help generate new hypotheses for development as full-fledged SPORE projects.