Fluid Structure Interactions Within the Human Larynx

描述(由申请人提供)：这项建议描述了一项关于发声过程中人类喉部内流体-结构相互作用现象的研究。声带的运动部分是由其表面的空气动力压力驱动的。在发声过程中，声带的弹性变形和与流经喉部的气流相关的表面压力之间存在着周期性的能量交换。为了开发准确的发声过程预测模型和准确估计组织内的应力，对相关的流体-结构相互作用机制的良好理解是至关重要的。这项拟议的研究的目的是彻底了解液体引起的喉组织振荡的机制，包括与假声带在发声中可能扮演的角色有关的方面。其目的是：1)使用喉部和假声带的自振物理模型进行详细的流动、运动学和声音测量；2)开发详细和准确的计算模型以及近似的降阶模型，以预测喉部和假声带的流体流动、辐射声音和组织变形；以及3)确定喉部正常和病理状态对喉动力学的影响，并阐明假声带的作用。基本发音过程将被分离和研究。不同的理论和物理模型将被用来交叉验证新的信息，这些信息连接着理想化的模型和真实的喉音。将对使用物理模型获得的数据与数值预测进行比较。这将允许验证数值模型，并加强我们对所涉及的物理现象的理解。总体目标是开发准确的计算机发音预测模型，最终可能有助于在语音临床做出准确的诊断决策，针对语音问题制定最佳干预策略，并实现高质量的发音语音合成。准确的应力计算也是必要的，对组织损伤的预测也很有用。这项研究计划是鲍灵格林州立大学和普渡大学的实验室之间的合作。

DESCRIPTION (provided by applicant): This proposal describes a study of fluid-structure interaction phenomena within the human larynx during phonation. The motion of the vocal folds is driven in part by the aerodynamic pressure on their surfaces. During phonation, there is a periodic exchange of energy between the elastic deformation of the vocal folds and the surface pressures associated with the airflow through the larynx. A good understanding of the associated fluid-structure interaction mechanisms is of utmost importance in order to develop accurate predictive models of phonatory processes, and accurate estimates of the stresses within the tissue. The purpose of the proposed research is to gain a thorough understanding of the mechanics of fluid-induced oscillations of the laryngeal tissue, including aspects related to the possible role of the false vocal folds in phonation. The aims are to: 1) perform detailed flow, kinematic, and sound measurements using a self oscillating physical model of the larynx and the false vocal folds; 2) develop detailed and accurate computational models as well as approximate reduced order models for the prediction of fluid flow, radiated sound, and tissue deformation of the larynx and false folds; and 3) determine the effects on laryngeal dynamics of normal and pathological conditions of the larynx, and clarify the role of the false vocal folds. Fundamental phonation processes will be isolated and studied. The different theoretical and physical models will be used to cross-validate new information that bridges from idealized models and real larynx phonation. Comparisons will be made between data obtained using the physical models and the numerical predictions. This will allow the validation of the numerical models, and reinforce our understanding of the physical phenomena involved. The overarching goal is to develop accurate computer prediction models of voice production that may eventually be useful for making precise diagnostic decisions in the voice clinic, targeting optimal intervention strategies for voice problems, and achieving high quality articulatory speech synthesis. Accurate stress calculations are also needed and useful for tissue damage predictions. This research program is a collaboration among laboratories at Bowling Green State University and Purdue University.