Novel utilisation of trigeminal stimulants as bioactive ingredients to design innovative and improved oral-care formulations in scientific and sustain

背景与目的世界卫生组织(2020)报告称，超过35亿人患有口腔疾病1，而牙齿健康不良已被科学证明与心脏病、糖尿病、肥胖症和口腔癌2有关。口腔保健品用于清洁口腔，保持良好的口腔卫生，在口腔疾病的日常预防中起着至关重要的作用。与主要使用薄荷化合物刺激凉爽感觉的传统口腔护理产品不同，这项建议的独特目的是)产生口腔中不同三叉神经刺激剂的功能的基础知识，并探索它们的潜在用途，以帮助设计更有效和更新颖的配方。

Background& Aims The World Health Organization (2020) reported thatmore than 3.5 billion people suffer from oral disease1, and poor dental health has been scientifically proven for itslink withheartdisease, diabetes, obesity,andmouth cancer2. Oral-care products, which areused to cleanse the oral cavityand maintain good oral hygiene, play a vital rolein the dailypreventionof oral disease. Unlike the traditional oral-care productsmainlyusingminty compoundsto stimulate a cooling sensation, this proposal uniquely aims toi)generate fundamental knowledgeon the functionality of differenttrigeminal stimulantsin the oral cavity andii)explore their potential use tohelpdesignmore efficacious and novelformulations.