ACT 7: AIDS & EMERGING INFECTIOUS DISEASES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项提议的主要目标是创建一个计划，以提高艾滋病和新发传染病的研究能力。之所以选择该方案的这两个重点，是因为该岛艾滋病毒的高发病率，以及新出现或再次出现的疾病对热带加勒比海岛屿波多黎各构成的真正威胁。多学科计划允许整合我们的基础和临床科学家所需的资源和专业知识，以实现他们的目标。该项目由两个部分组成：一个核心设施，提供医学校园内不易获得的最先进设备；以及一个为新教师、博士后研究员和学生提供培训的部分。此外，该计划还整合了我们的临床和基础研究人员，以便能够更快地应对当地社区面临的新的传染病威胁。这项建议包括的四个最初进行中的项目是：项目1“UPR成人艾滋病临床试验单元-幼稚患者的艾滋病毒基因分型”项目2“趋化因子受体在艾滋病毒经胎盘感染中的作用”项目3“登革2型包膜DNA疫苗评价研究”项目4“鉴定啮齿动物疟疾中的多药耐药基因”。这些项目涉及与波多黎各和加勒比人口有关的健康差距问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main objective of this proposal was to create a program to enhance research capabilities in AIDS and Emerging Infectious Diseases. These two foci of the program were chosen because of the high incidence of HIV on the island, as well as the real threat which emerging or re-emerging diseases pose to Puerto Rico, a tropical Caribbean island. the multidisciplinary program allowed the integration of the resources and expertise needed by our basic and clinical scientists to accomplish their goals. The project consisted of two components: a core facility providing state-of-the-art equipment not easily available at the Medical Sciences Campus; and a training component for new faculty, post-doctoral fellows and students. In addition, this program served to integrate our clinical and basic research faculty in order to be equipped to respond more rapidly to new infectious disease threats to the local community. The four original ongoing projects included in this proposal were: Project No. 1 "UPR Adult AIDS Clinical Trials Unit - HIV genotyping in naive patients" Project No. 2 "Role of Chemokine Receptors in HIV Infection Across the Placenta" Project No. 3 "Evaluation Studies of Dengue-2 Envelope DNA-Based Vaccine" Project No. 4 "Identification of Multidrug Resistant Genes in Rodent Malaria". These projects address health disparities issues relevant to the Puerto Rican and Caribbean populations.