Effectiveness of PTSD Treatment: PE vs. Zoloft

描述（由应用程序提供）：创伤后应激障碍（PTSD）是一种慢性和使人衰弱的疾病，终身患病率范围为美国人口的8%-14%。因此，开发有效且具有成本效益的PTSD治疗方法势在必行。延长暴露疗法（PE）和舍曲林（MED）对PTSD都有疗效。然而，我们对这些治疗形式的可比有效性知之甚少，也不知道什么因素会影响接受/拒绝治疗和完成/辍学。在这次为期五年的两地研究中，我们将研究这些问题。这项合作R 01赠款将在华盛顿大学进行，由Zoellner博士指导，在凯斯西储大学进行，由Feeny博士指导。我们将进行一项混合疗效试验，其中女性和男性创伤受害者将被随机分配到选择或没有选择的治疗条件。在选择条件下，参与者将在长期暴露和舍曲林之间进行选择。在没有选择的情况下，参与者将被随机分配到长期暴露或舍曲林。通过精神病理学和更广泛的功能测量来评估结果，将通过24个月的随访进行评估。拟议研究的结果将告知临床医生PE和MED的相对短期和长期有效性，提供有关这些治疗如何影响更广泛的功能障碍测量的信息，提供有关决策因素的信息，以最大限度地提高治疗利用率，并提供有关PE和MED治疗慢性PTSD的成本效益的重要信息。

DESCRIPTION (provided by application): Posttraumatic stress disorder (PTSD) is a chronic and debilitating condition, with lifetime prevalence rates ranging from 8%-14% of the US population. Thus, the development of efficacious and cost-effective treatments for PTSD is imperative. Both prolonged exposure therapy (PE) and sertraline (MED) are of established efficacy for PTSD. Yet, we know very little about the comparable effectiveness of these forms of treatment, nor what factors influence treatment acceptance/refusal and completion/drop-out. In this five-year, two-site study, we will examine these issues. This collaborative R01 grant will be conducted at the University of Washington under the direction of Dr. Zoellner and at Case Western Reserve University under the direction of Dr. Feeny. We will conduct a hybrid efficacy-effectiveness trial in which female and male trauma victims will be randomly assigned to either choice or no choice treatment conditions. In the choice condition, participants will choose between prolonged exposure and sertraline. In the no choice condition, participants will be randomly assigned to either prolonged exposure or sertraline. Outcome, as measured by both psychopathology and broader functioning measures, will be assessed through 24-month follow-up. The results of the proposed research will inform clinicians about the relative short-term and long-term effectiveness of PE and MED, provide information about how these treatments influence broader measures of functional impairment, provide information regarding decision making factors in order to maximize treatment utilization, and provide important information about cost effectiveness of both PE and MED for chronic PTSD.