Effectiveness of PTSD Treatment: PE vs. Zoloft

描述(由应用程序提供)：创伤后应激障碍(PTSD)是一种慢性和衰弱的疾病，其终生患病率在美国人口中从8%到14%不等。因此，开发有效且经济有效的创伤后应激障碍治疗方法势在必行。长期暴露疗法(PE)和舍曲林(MED)对创伤后应激障碍都有确定的疗效。然而，我们对这些治疗形式的可比疗效知之甚少，也不知道什么因素影响治疗的接受/拒绝和完成/退出。在这项为期五年、为期两个地点的研究中，我们将研究这些问题。这项合作的R01赠款将在佐尔纳博士的指导下在华盛顿大学进行，并在凯斯西储大学的芬尼博士的指导下进行。我们将进行一项混合疗效-效果试验，将女性和男性创伤受害者随机分配到选择或不选择治疗条件。在选择条件下，参与者将在长期暴露和舍曲林之间进行选择。在没有选择的情况下，参与者将被随机分配到长期暴露或舍曲林。以精神病理学和更广泛的功能指标衡量的结果将通过24个月的随访进行评估。拟议的研究结果将使临床医生了解PE和MED的相对短期和长期有效性，提供有关这些治疗如何影响更广泛的功能损害测量的信息，提供有关决策因素的信息，以便最大限度地利用治疗，并提供有关PE和MED治疗慢性PTSD的成本效益的重要信息。

DESCRIPTION (provided by application): Posttraumatic stress disorder (PTSD) is a chronic and debilitating condition, with lifetime prevalence rates ranging from 8%-14% of the US population. Thus, the development of efficacious and cost-effective treatments for PTSD is imperative. Both prolonged exposure therapy (PE) and sertraline (MED) are of established efficacy for PTSD. Yet, we know very little about the comparable effectiveness of these forms of treatment, nor what factors influence treatment acceptance/refusal and completion/drop-out. In this five-year, two-site study, we will examine these issues. This collaborative R01 grant will be conducted at the University of Washington under the direction of Dr. Zoellner and at Case Western Reserve University under the direction of Dr. Feeny. We will conduct a hybrid efficacy-effectiveness trial in which female and male trauma victims will be randomly assigned to either choice or no choice treatment conditions. In the choice condition, participants will choose between prolonged exposure and sertraline. In the no choice condition, participants will be randomly assigned to either prolonged exposure or sertraline. Outcome, as measured by both psychopathology and broader functioning measures, will be assessed through 24-month follow-up. The results of the proposed research will inform clinicians about the relative short-term and long-term effectiveness of PE and MED, provide information about how these treatments influence broader measures of functional impairment, provide information regarding decision making factors in order to maximize treatment utilization, and provide important information about cost effectiveness of both PE and MED for chronic PTSD.