Genomic epidemiology of SARS-CoV-2 in EastAnglia

多亏了新冠肺炎基因组学英国联盟(COG-UK)，英国在SARS-CoV-2基因组测序方面处于世界领先地位。Quadram研究所，特别是佩奇小组，一直处于对SARS-CoV-2基因组测序的前沿，在18个月内测序了超过6万份，使诺福克成为英格兰测序最密集的地区。这个项目的重点是更深入地研究大流行是如何在该区域展开的，以深入了解基因组流行病学，这将有助于为今后的传染病管理提供信息。利用基因组学，目的是寻找以下问题的答案：阿尔法变种是如何在该地区传播的，医院疫情期间发生了什么，不同的老年人是否以不同的方式传播病毒，监狱等封闭环境中的样本是否与当地社区有关，随机社区监测的趋势是否与医院的趋势相符？这是建立在现有研究的基础上的，这些研究着眼于大流行的早期(https://dx.doi.org/10.1099%2Fmgen.0.000589).

The UK is a world leader in SARS-CoV-2 genome sequencing thanks to the COVID-19 Genomics UK Consortium (COG-UK). The Quadram Institute, in particular the Page group, have been at the forefront of sequencing SARS-CoV-2 genomes with over 60,000 sequenced in 18 months making Norfolk the most densely sequenced region of England. This project focuses on looking more deeply at how the pandemic unfolded within this region to gain a deep understanding of the genomic epidemiology which will help to inform future management of infectious diseases. Using genomics, the aim is to seek answers to questions like: how did the Alpha variant spread within the region, what happened during hospital outbreaks, did different aged people spread the virus in different ways, were samples from closed environments like prisons linked to the local community, did trends from random community surveillance match up with trends seen in hospitals? This builds upon existing research which looked at the early days of the pandemic (https://dx.doi.org/10.1099%2Fmgen.0.000589).