The function and regulation of hyperactive estrogen receptor proteins in breast cancer

一个学生奖学金可用于研究雌激素受体融合蛋白，以了解它们的过度活跃如何驱动乳腺癌。这是一个多学科项目，将提供跨癌细胞生物学，先进的细胞成像和生物化学的良好培训机会。超过70%的乳腺癌是雌激素受体（ER）阳性。ER响应激素驱动基因表达的变化，是关键的治疗靶点。基因组不稳定性是癌症的标志，导致基因组重排，产生ER融合蛋白。这些蛋白质是过度活跃的，并且是侵袭性、治疗抗性乳腺癌中的复发性发现。该项目将揭示多动症是如何发生的，以及如何使用先进的细胞成像，基因表达测定和蛋白质生物化学的组合进行调节。该项目的完成将为指导未来的治疗干预提供一个框架，并有助于诊断携带这些过度活跃的融合蛋白的患者。谢菲尔德肿瘤学和代谢学系（www.toseland-lab.com Twitter：@chris.toseland）和Mark泄漏教授（系物理学在约克https：//www.york.ac.uk/physics/people/leake/）。该团队在使用多种先进的显微镜方法来研究DNA-蛋白质相互作用的调节方面具有出色的背景。您将加入谢菲尔德的协作支持研究社区，拥有世界领先的单分子和核酸研究中心（http：www.imagine-imaginglife.com和www.genome.sheffield.ac.uk）以及活跃，友好和活泼的博士生群体，该群体定期举办社交活动以及网络和职业发展机会。您还将成为约克生命物理学小组的一员，该小组提供连接物理和生命科学的多学科专家网络。我们致力于支持学生的职业发展，鼓励参加国际和英国会议，会议和培训课程，以培养您的研究技能和兴趣。

A studentship is available to study estrogen receptor fusion proteins to understand how their hyperactivity drives breast cancer. This is a multidisciplinary project which will provide excellent training opportunities across cancer cell biology, advanced cellular imaging and biochemistry. Over 70% of breast cancers are Estrogen Receptor (ER) positive. The ER drives changes in gene expression in response to hormones and is a critical therapeutic target. Genomic instability, a hallmark of cancer, leads to genomic rearrangements which generate ER fusion proteins. These proteins are hyperactivity and are a recurrent finding in aggressive, therapy-resistant breast cancer. This project will unravel how hyperactivity occurs and how it may be regulated using a combination of advance cellular imaging, gene expression assays and protein biochemistry. Completion of this project will provide a framework for guiding future therapeutic interventions and aid the diagnosis of patients carrying these hyperactive fusion proteins.You will be part of a new multidisciplinary collaboration between Dr. Chris Toseland (Dept. of Oncology and Metabolism in Sheffield www.toseland-lab.com Twitter: @chris.toseland) and Prof. Mark Leake (Dept. of Physics in York https://www.york.ac.uk/physics/people/leake/). The team has an excellent background in using multiple advanced microscopy approaches to study the regulation of DNA-protein interactions.You will join a collaborative, supportive research community in Sheffield, with world-leading single molecule and nucleic acid research centres (http://www.imagine-imaginglife.com and www.genome.sheffield.ac.uk) and an active, friendly and lively PhD student cohort, which hosts regular social events alongside networking and career development opportunities. You will also be part of the Physics of Life Group at York which provides a multidisciplinary network of experts linking physical and life sciences.We are committed to supporting the career development of our students, encouraging attendance at both international and UK meetings, conferences and training courses to develop your research skills and interests.