Reproductive Biology: Early Pregnancy and Development

描述（由申请人提供）：该计划的目标是准备博士后学员建立独立的研究事业在性腺功能，早期妊娠和胚胎发育通过植入领域。培训计划将包括三个要素：独立的实验室研究，小组研讨会和与生殖科学中心联合举办的其他活动，以及研究伦理和动物福利方面的正式课程，以及将提高受训者研究专业知识的科目。这项独立研究将在一个实验室进行，该实验室由受训者从12名生殖和发育生物学各方面的领导者中选出。这个培训小组的成员已经建立了NIH资助的项目，并培养了超过86名博士后研究员。研究领域包括受精，着床前发育，滋养层-子宫相互作用，着床和早期妊娠的免疫生物学，以及性腺功能的调节，睾丸和胚胎发育过程中的基因表达。这个小组的实力是通过成员之间的合作得到加强，这一点可以从联合出版物、赠款和学生的记录中得到证明。该计划将利用现有的生殖科学中心，包括21名主要研究人员和78名额外的工作人员和受训人员，以提供更好的培训环境。生殖科学中心赞助了一个积极的研讨会计划，并主办了生殖生物学区域会议，为学员提供了更多的机会来展示他们的工作。学员的招聘，选拔和指导将通过内部咨询委员会进行协调，与所有参与教师的投入，并与外部顾问协商，他们将每年与该集团会面一次。已获得博士学位的申请人生物科学学位或D.V.M.或者医学博士学位和谁表现出对生殖生物学研究的承诺将被考虑进入该计划。重点将放在招募代表不足的少数民族参加该方案。在第一个供资期间选出的六名受训人员的记录令人印象深刻，四名受训人员中有两名完成了培训，担任了教员职务，一名终身教职人员和一名研究人员。该计划的整体成功将最终由这些学员在建立独立研究计划后的贡献来衡量。

DESCRIPTION (provided by applicant): The objective of this program is to prepare post-doctoral trainees to establish independent research careers in the areas of gonadal function, early pregnancy and embryonic development through implantation. The training program will consist of three elements; independent laboratory research, group seminars and other functions held jointly with the Center for Reproductive Sciences, and formal course work in research ethics and animal welfare, as well as subjects that will enhance the trainee's research expertise. The independent research will occur in a laboratory selected by the trainee from a group of 12 scientists who are leaders in various aspects of reproductive and developmental biology. The members of this training group have well established NIH-funded programs and have trained more than 86 postdoctoral fellows. Areas of study include fertilization, pre-implantation development, trophoblast-uterine interactions, the immunobiology of implantation and early pregnancy, as well as regulation of gonadal function, gene expression during testis and embryonic development. The strength of this group is enhanced by collaboration among the members as evidenced by the record of joint publications, grants, and students. This program will take advantage of an existing Center for Reproductive Sciences comprising 21 principal investigators and 78 additional staff and trainees to provide an enhanced training environment. The Center for Reproductive Sciences sponsors an active seminar program and hosts a regional conference in reproductive biology, which provides additional opportunities for trainees to present their work. The recruitment, selection and guidance of trainees will be coordinated through an Internal Advisory Committee, with input from all participating faculty and in consultation with an External Advisor, who will meet with the group once each year. Applicants who have been awarded a Ph.D. degree in one of the biological sciences, or a D.V.M. or M.D. degree and who demonstrate a commitment to research in reproductive biology will be considered for entry into the program. An emphasis will be placed on recruiting under represented minorities into the program. The records of the six trainees selected during the first funding period are impressive, with two of the four trainees who have completed their training having assumed faculty positions, one tenure track and one research track. The overall success of the program will ultimately be measured by the contributions of these trainees after they have established independent research programs.