Mechanisms of IL-18 Mediated Regulation of GVHD and GVL

描述（由申请人提供）：这是一个K 08奖的申请。候选人Pavan Reddy博士是密歇根大学血液和骨髓干细胞移植项目的初级教员。Reddy博士的长期目标是成为实验性骨髓移植（BMT）和移植物抗宿主病（GVHD）领域的独立实验室研究者。 该申请详细介绍了一个四点计划，将为Reddy博士提供必要的工具，以发展他的研究事业，使他能够实现这一目标，并最终成为成人骨髓移植的领导者。 首先，申请人将通过参加密歇根大学研究生院的几门免疫学课程，获得细胞和分子免疫学的先进概念和理论背景，特别强调淋巴细胞和细胞因子生物学。 其次，申请人将通过完成其关于IL-18调节急性GVHD的研究项目获得额外的BMT研究技能和技术。Reddy博士已经从这个项目中获得了令人印象深刻的初步数据，这些数据已发表在《实验医学杂志》上。 第三，申请人将通过参加BMT研究研讨会和会议，参加国家血液学和BMT会议以及编写科学手稿，获得成功的研究生涯所需的书面和口头高级沟通技能。 第四，申请人在整个获奖过程中的进展将由高级研究人员和学术领导人组成的咨询委员会监督。申请人的赞助商保证，在此期间，Reddy博士80%的精力将用于他的研究。

DESCRIPTION (provided by applicant): This is an application for a K08 award. The candidate,Dr. Pavan Reddy, is a junior faculty member in the Blood and Marrow Stem Cell Transplantation Program at the University of Michigan. Dr. Reddy's long-term goal is to become an independent laboratory investigator in the field of experimental bone marrow transplantation (BMT)and graft versus host disease (GVHD). This application details a four point program that will provide the necessary tools for Dr. Reddy to develop his research career such that he can achieve this goal and eventually become a leader in adult bone marrow transplantation. First, the applicant will obtain advanced conceptual and theoretical background in cellular and molecular immunology with particular emphasis on lymphocyte and cytokine biology by participating in several immunology courses in the University of Michigan graduate school. Second, the applicant will acquire additional BMT research skills and techniques through the completion of his research project regarding the modulation of acute GVHD by IL-18. Dr. Reddy has already achieved impressive preliminary data from this project that have been published in the Journal of Experimental Medicine. Third, the applicant will acquire advanced communication skills, both written and oral, required for a successful research career through participation in BMT research seminars and conferences, participation in national Hematology and BMT meetings and the preparation of scientific manuscripts. Fourth, the applicant's progress throughout the award will be monitored by an advisory committee of senior researchers and academic leaders. The applicant's sponsor guarantees that 80% of Dr. Reddy's effort will be devoted to his research during this award.