Ultrasonic microbubbles as a therapy for biofilm targeting in bone repair

在这个博士生阶段，我们希望确定超声响应的微泡是否能刺激骨感染中的生物膜扩散。感染是植骨失败的主要原因之一，也是急性创伤性骨折发病率的主要来源。微泡可以被注射到循环中，并可以使用超声波能量远程刺激，为非侵入性靶向感染的骨骼提供了机会。该项目将帮助我们了解和确定生物膜扩散和抗生素输送所需的超声波参数。同时，我们希望确定刺激候选抗生素组织渗透的参数。在骨组织的器官模型中。该项目将导致在新兴工程研究的跨学科领域的充满活力、竞争激烈的团队中培养一名博士生，并直接专注于临床翻译。它将使我们能够确定用于军事部署的新型设备/技术的设计参数。它还将与我们专注于临床的目标紧密结合，并将为未来的研究巩固伙伴关系。

In this PhD studentship, we wish to determine whether ultrasound-responsive microbubbles stimulate biofilm dispersal in bone infections. Infections are one of the primary reasons why bone implants fail, and is a major source of morbidity in acute traumatic bone fracture. Microbubbles, which can be injected into the circulation and which can be stimulated remotely using ultrasound energy, offer an opportunity for targeting infected bone noninvasively. The project will help us understand and determine the ultrasound parameters necessary for biofilm dispersal and antibiotic delivery. In parallel we wish to determine the parameters that stimulation tissue penetration of candidate antibiotics. in organotypic models of bone tissue. The project will lead to the training of a PhD student in a vibrant, competitive group in an interdisciplinary area of emerging engineering research with a direct clinical translation focus. It will enable to us to determine the design parameters for a novel device/technology for deployment in the military. It will also integrate closely with our clinically-focussed aims and will cement a partnership for future studies.