Interventions for Financially Disadvantaged Mothers

申请以病人为中心的研究(K-24)职业中期研究人员奖 请求支持候选人增加对初级临床研究人员的指导，并加强她以患者为导向的研究。这项研究的重点是针对经济困难(FD)母亲的干预措施，因为这些妇女患有情绪和焦虑症的风险很高，特别是与人际暴力有关的障碍，如创伤后应激障碍(PTSD)和严重抑郁症。尽管与创伤后应激障碍和严重抑郁症相关的痛苦和明显的损害，但很少有系统地测试将患有这些障碍的FD妇女包括在内的干预措施，因为工具障碍(例如，儿童保育、交通工具)、怀孕或母乳喂养等因素将这些妇女排除在参与临床试验或获得治疗的范围之外。作为一名研究人员 在女性心理健康，特别是创伤、创伤后应激障碍和严重抑郁症方面有广泛的背景，候选人建议继续并扩大她对这一未被研究、服务不足和脆弱的女性群体的以患者为导向的研究。这项建议的主要目的是利用以患者为导向的研究中职业中期研究员奖腾出的时间，增加候选人对与她未来研究相关的几个领域的知识，并开发、评估和传播有关FD母亲干预的新信息。至 为此，职业发展计划在以下方面增加了应聘者的经验、知识和技能：1)儿童和母婴互动评估培训和父母干预培训。2)统计、干预研究设计和方法，以及成本问题。职业发展计划还建议：1)扩大候选人对初级调查人员的指导，目标是吸引他们从事以患者为导向的研究；2)通过教育专业人员、立法者和公众，提高对FD女性生活中精神健康障碍和人际暴力的认识。该应用程序的研究计划侧重于正在进行的两项针对FD妇女的R-21干预研究、正在进行的研究、待定研究和针对FD母亲的拟议干预研究。总而言之，这一奖项将为候选人的职业发展、指导以及正在进行的、以患者为导向的针对高风险和研究不足的女性群体的新研究提供关键支持。

This application for a Mid-Career Investigator Award in Patient-Oriented Research (K-24) requests support for the candidate to increase mentoring of beginning clinical investigators and enhance her patient-oriented research. This research focuses on interventions for financially-disadvantage (FD) mothers because these women are at high risk for mood and anxiety disorders, in particular, disorders related to interpersonal violence, such as posttraumatic stress disorder (PTSD) and major depression. Despite the distress and marked impairment associated with PTSD and major depression, few interventions have been systematically tested that include FD women with these disorders, because factors, such as instrumental barriers (e.g., child care, transport), pregnancy, or breastfeeding have excluded these women from participation in clinical trials or access to treatment. As a researcher with an extensive background in the mental health of women, in particular trauma, PTSD, and major depression, the candidate proposes to continue and expand her patient-oriented research on this understudied, underserved, and vulnerable group of women. The chief aim of this proposal is to use time liberated by the Mid-Career Investigator Award in Patient-Oriented Research to increase the candidate's knowledge of several areas relevant to her future research and to develop, evaluate and disseminate new information on interventions for FD mothers. To this end, the career development plan increases the candidate's experience, knowledge, and skills in the following areas: 1) Child and maternal-infant interaction assessment training and parent intervention training. 2) Statistics, intervention study design and methodology, and cost issues. The career development plan also proposes to 1) expand the candidate's mentoring of beginning investigators with the goal of attracting them to a career in patient-oriented research, and 2) increase awareness of mental health disorders and interpersonal violence in the lives of FD women by educating professionals, legislators, and the public. This application's research plan focuses on two ongoing R-21 studies of interventions with FD women, ongoing research, pending research, and proposed intervention research with FD mothers. In summary, this award would provide critical support for the candidate's career development, mentoring, and ongoing and new patient-oriented research on a high-risk and understudied group of women.