Industrial Pollutants and Risk of Non-Hodgkins Lymphoma

描述(申请人提供)：工业污染一直被怀疑是非霍奇金淋巴瘤(NHL)的一个原因，特别是因为这种癌症的发病率在20世纪后半叶急剧增加，略落后于美国工业生产的扩张时期。尽管有一个令人信服的假设，但很少有严谨的研究检验非霍奇金淋巴瘤与特定工业污染物之间的联系。随着桌面地理信息系统(地理信息系统)和工业位置和排放公共数据库的可用性和易用性不断提高，这类研究正变得更加容易实施。研究人员提出了一项关于长期环境暴露于工业污染物与非霍奇金淋巴瘤风险的病例对照研究。拟议研究的对象是病例(n=855)和对照(n=781)，来自NCI赞助的现有多地点研究，从洛杉矶县以及西雅图和底特律大都市地区招募。居住历史将被用来描述在病因学感兴趣的30年时间段内受试者的位置。出于暴露评估的目的，将创建一个地理数据库，以包含有关行业的信息，包括地点、运营类型和排放，这些信息记录在各种来源中，包括环境保护局的有毒物质释放清单(TRI)和加利福尼亚州、华盛顿州和密歇根州的历史商业目录。我们将研究与特定行业类型有关的非霍奇金淋巴瘤风险，包括石油精炼和纸浆和造纸厂。在根据排放量和气象数据制定暴露等值线后，将检查与感兴趣的特定工业污染物相关的风险，包括溶剂、多环芳烃和二恶英。除了使用地理信息系统开发详细的暴露指标外，这项研究还拥有关于长期住宅史和潜在混杂因素的丰富现有数据，将使调查人员能够对目前关于非霍奇金淋巴瘤环境病因的知识状况做出有益贡献。

DESCRIPTION (provided by applicant): Industrial pollution has been suspected as a cause of non-Hodgkin lymphoma (NHL) particularly because the rates of this cancer increased dramatically during the latter half of the 20th century, lagging slightly behind a period of expanded industrial production in the United States. Despite a compelling hypothesis, there have been few rigorous studies which examined the association between NHL and specific industrial pollutants. Such studies are becoming more readily implemented with the increasing availability and ease-of-use of desktop geographic information systems (GIS) and public databases of industry location and emissions. The investigators propose a case-control study of long-term environmental exposure to industrial pollutants and risk of NHL. Subjects for the proposed study are cases (n=855) and controls (n=781) from an existing NCI-sponsored multi-site study, recruited from Los Angeles County and the Seattle and Detroit metropolitan regions. Residential histories will be used to characterize the location of subjects during the 30-year time period of etiologic interest. A geodatabase will be created for exposure assessment purposes, to contain information on industries including location, operation type, and emissions, as recorded in various sources including the Environmental Protection Agency's Toxics Release Inventory (TRI) and historical business directories from California, Washington, and Michigan States. We will examine NHL risk in relation to specific types of industry, including petroleum refining and pulp and paper mills. The risk associated with specific industrial pollutants of interest, including solvents, polycyclic aromatic hydrocarbons, and dioxins, will be examined after developing exposure contours based on emissions quantities and meterologic data. The study's wealth of existing data on long-term residential history and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make a useful contribution to the current state of knowledge regarding environmental causes of NHL.