Application of micellar catalysis to forbidden on-DNA reactions

DNA编码库为寻找药物发现的起点提供了一种令人兴奋的新技术。它们由一系列小分子组成，共价连接到对每种化合物特异性的独特DNA标签上，从而实现有效的蛋白质靶点筛选。尽管DNA编码的文库提供了目前的前景，但许多传统的有机合成方法与DNA标记的底物不相容，例如，导致DNA损伤的酸性和氧化条件。该项目将探索最近开发的胶束方法的范围，以促进这些传统上禁止的反应，通过将有机反应物定位到分子的底物部分，并保护DNA标签免受反应条件的影响。

DNA-encoded libraries provide an exciting new technology for finding start points for drug discovery. They consist of a collection of small molecules, covalently attached to a unique DNA-tag that is specific to each compound, enabling efficient protein target screening. Despite the current promise offered by DNA-encoded libraries, many traditional methods of organic synthesis are not compatible with DNA-tagged substrates, for example, acidic and oxidising conditions which cause DNA damage. This project will explore the scope for recently developed micellar methodology to facilitate these traditionally forbidden reactions, by localising the organic reactants to the substrate portion of the molecule and protecting the DNA-tag from the reaction conditions.