X-Ray Detector for the Life Sciences CAT at the APS

描述(由申请人提供)：本提案要求获得资金，用于在高级光子源生命科学(LS-CAT)部门的初始插入设备光束线上进行结构生物学研究的最先进仪器。这条光束线将利用LS-CAT将安装的两(2)个波荡器中的第一个的辐射，并将为大分子结晶学提供可调、高强度的光束线。LS-CAT已经获得了包括这条光束线在内的一期建设资金，即将开始建设。预计光束线将于2005年底首次使用。生命科学协作访问团队是一个学术和研究机构联盟，由西北大学、密歇根州立大学、密歇根大学、韦恩州立大学、范安德尔研究所、伊利诺伊大学厄巴纳-香槟分校和威斯康星大学组成。参加LS-CAT的研究人员涉及尖端结构生物学，重点是膜蛋白、信号和蛋白质运输中的多组分系统、参与基因组复制、修复、重组和调控的蛋白质-核酸复合体，以及作为机械学研究或生物技术新靶点的酶。许多与LS-CAT相关的研究人员已经达到了小晶体尺寸或大单位电池的技术障碍，这使得获得对科学进步至关重要的专用同步加速器源至关重要。所要求的仪器是一种大面积的CCD探测器，适用于单个大分子和具有大单胞的络合物的高分辨率研究。所要求的探测器将具有大表面积、高空间分辨率和快速读出，这些对于允许调查人员解决日益困难的结构问题至关重要。

DESCRIPTION (provided by applicant): This proposal requests funds for acquiring state of the art instrumentation for structural biology research on the initial insertion device beamline in the Life Sciences (LS-CAT) sector at the Advanced Photon Source. This beamline will utilize radiation from the first of two (2) undulators that LS-CAT will install and will provide a tunable, high intensity beamline for macromolecular crystallography. Funds for the Phase I construction, which includes this beamline, have already been obtained by LS-CAT and construction is about to begin. It is expected that first use of the beamline will occur in late 2005. The Life Sciences Collaborative Access Team is a consortium of academic and research institutions comprised of Northwestern University, Michigan State University, the University of Michigan, Wayne State University, the Van Andel Institute, the University of Illinois at Urbana-Champaign, and the University of Wisconsin. The investigators participating in LS-CAT are involved in cutting edge structural biology with special emphasis in membrane proteins, multicomponent systems in signaling and protein transport, protein-nucleic acid complexes involved in genome replication, repair, recombination and regulation, and enzymes that are novel targets for mechanistic studies or biotechnology. Many of the researchers associated with LS-CAT have already reached the technical barriers of small crystal size or large unit cells that make access to a dedicated synchrotron source essential to the scientific progress. The instrumentation requested is a large area CCD detector suitable for high resolution studies of individual macromolecules and complexes with large unit cells. The requested detector will have the large surface area, high spatial resolution and rapid read-out that are essential for allowing investigators to tackle increasingly difficult structural problems.