Hypervalent iodine reagents for late-stage functionalisation

杂原子烷基化是药物化学中应用最广泛的反应之一。然而，传统的方法（Williamson/Mitsunobu反应；金属催化交叉偶联）是有限的，需要可靠的方法来快速和选择性地烷基化受阻的亲核试剂。本博士项目的目的是解决这一挑战，并为后期烷基化开发新的高价碘试剂。项目的具体重点将与成功的申请人合作确定。

Heteroatom alkylation is one of the most widely used reactions in medicinal chemistry. However, traditional approaches (Williamson/Mitsunobu reactions; metal-catalysed cross-coupling) are limited and there is a need for reliable methods for quick and selective alkylation of hindered nucleophiles. The aim of this PhD project is to address this challenge and develop new hypervalent iodine reagents for late-stage alkylation. The specific focus of the project will be defined in collaboration with the successful applicant.