Developing -omics methods to determine if skin active treatments can restore a youthful extracellular matrix in pre- and post-menopausa

在BBSRC“推进生物科学前沿交付”的职权范围内，该项目将通过探索细胞和组织的机械调节与昼夜节律之间的基本关系来增加我们对生命规则的理解。该项目的基本科学要素将得到“变革性技术”的支持：多组学分析（转录组学和蛋白质组学），用先进的生物信息学和计算机建模方法进行解释。成功的申请人将加入一个由生物学家，物理学家，工程师和数学家组成的多学科团队，因此将有机会发展广泛的技能。该项目的产出将直接有助于BBSRC的“战略挑战”，即“对健康的综合理解”：通过研究昼夜节律和机械感知能力在衰老过程中如何以及为什么受到抑制，我们将能够指导战略，以改善整个生命过程中组织的健康维护。

Within the BBSRC remit of 'advancing the frontiers of bioscience deliver', this project will increase our 'understanding [of] the rules of life' by exploring the fundamental relationships between mechanical regulation of cells and tissues, and circadian rhythm. The basic science elements of this project will be supported by 'transformative technologies': multi-omics analysis (transcriptomic and proteomic), interpreted with advanced bioinformatic and computer-modelling approaches. The successful applicant will join a multi-disciplinary team of biologists, physicists, engineers and mathematicians, and will therefore have opportunity to develop a wide range of skills. Outputs from the project will directly contribute to the BBSRC's 'strategic challenge' that looks towards an 'integrated understanding of health': by examining how and why circadian and mechanosensing capacities are dampened in ageing we will be able to direct strategies to improve healthy maintenance of tissue throughout the life course.