Laser Spectrometry Development for Isotopic Analysis in Environmental and Medical Applications

将研究红外吸收激光光谱法的潜力，用于二氧化碳和甲烷中稳定同位素和放射性碳的低水平非常高精度测量的可追溯性，与环境监测和药物发现应用有关。特别是碳-14是许多过程的理想放射性示踪剂，该项目将最终发展这些测量。(1)随着英国向“净零碳”过渡，将需要新的和改进的方法来验证工业排放和大气成分。通过对大气中碳14的测量，可以估计化石燃料中二氧化碳和甲烷的比例。(2)C-14作为示踪剂对于快速和具有成本效益的药物开发至关重要，特别是用于治疗癌症。它用于药物开发的早期疗效阶段，以了解人体在吸收，分布，代谢和消除（ADME）方面如何处理药物。

will investigate the potential towards IR-absorption laser spectrometry for traceability of low-level very high precision measurements of stable isotopes and radiocarbon in carbon dioxide and methane, relevant for environmental monitoring and drug discovery applications. Carbon-14 in particular is an ideal radioactive tracer for many processes and this project will culminate in the development of these measurements. (1) As the UK transitions towards 'net zero carbon', new and improved methods of verifying industrial emissions and atmospheric composition will be required. Atmospheric C-14 measurements allow for the estimation of the fossil-fuel fraction of CO2 and CH4. (2) C-14 as a tracer is vital for the rapid and cost-effective development of drugs, notably for the treatment of cancer. It is used in the early efficacy stage of drug development to understand how the human body will handle the drug in terms of the absorption, distribution, metabolism and elimination (ADME).