IN VIVO EXPERIMENTATION CORE

核心B，体内实验核心(Ivec)的目的是提供后勤支持、专业知识 为以小鼠为模式生物体内检测ETS基因功能提供指导。这个核心 由五个部分组成，包括：(一)转基因小鼠品系的维护和饲养；(二) 新型转基因模型的建立(三)乳腺形态计量学和组织学分析(四) 超低温保存和(V)报告基因分析。这一核心结构确保了访问最先进的 现有转基因和新转基因研究乳腺肿瘤发展和转移的技术 老鼠模型。与个体化相比，体内实验集中化有几个明显的优势 实验，包括更高的效率、实验条件的一致性(这有助于直接 数据比较)，为制定跨项目的计划或假设提供灵感来源 实验(例如，突变菌株的杂交)和快速适应新出现的方法。 因此，这个核心将是一个对个人需求做出最大反应的动态单位 无论是目前的项目，还是在进展过程中出现的项目。

The purpose of Core B, the In Vivo Experimentation Core (IVEC) is to provide logistical support, expertise and guidance for examining Ets gene function in vivo by using the mouse as model organism. This core consists of five components, including, (i) maintenance and husbandry of transgenic mouse strains, (ii) generation of new transgenic models, (iii) morphometrical and histological analysis of mammary gland (iv) cryopreservation, and (v) reporter gene analysis. This core structure ensures access to state-of-the-art technology to for studying mammary gland tumor development and metastasis in existing and new transgenic mouse models. Centralizing in vivo experimentation has several distinct advantages over individualized experimentation, including greater efficiency, uniformity of experimental conditions (which facilitates direct data comparison), providing a source of inspiration for developing plans or hypotheses for cross-project experimentation (e.g. crossing of mutant strains), and rapid adaptation to emerging new methodologies. Consequently, this core will be a dynamic unit with maximal responsiveness to the needs of the individual projects both at present, and as they arise during their progress.