Ultra-High Resolution Magnetometers Based on APF SQUIDs

说明：说明应用程序的广泛、长期目标和具体目标，并参考该项目与健康相关的内容。描述 简明扼要地介绍实现这些目标的研究设计和方法。避免总结过去的成就和使用第一人称。这篇摘要 是为了在脱离应用程序时对提议的工作进行简洁而准确的描述。如果应用程序得到资助，则此 原样的描述将成为公开信息。因此，不包括专有/机密信息。不要超过空格 但前提是。 提出的研究目标是开发超高分辨率、薄膜低温 超导(LTS)SQUID磁强计(UHRSM)，带有集成拾取回路和其他 正反馈(APF)。UHRSM将进行优化，以成像由 动作电流、损伤和发育电流、剩余磁化强度和磁化率 分离的活组织和小型实验动物制剂。作为HYPRES之间的合作努力 和几个研究机构，包括范德比尔特大学的生命态物理，模拟SQUID 磁力计正被开发用于成像应用。为了将SQUID用于这些 应用中，它们的电压由升压变压器放大，因此可以用空间进行测量 温度电子学。升压变压器的使用需要大量的外围电子设备 线性化，从而限制了实际系统中SQUID磁强计通道的数量。我们是 建议开发一种新型的带有有源电力滤波器的鱿鱼，它不需要变压器，因此 极大地简化了外围电子设备。提出的APF Squid集成了片上反馈 和鱿鱼卷在一起。这可以显著增加器件的增益，并且结果不会升压 需要变压器才能读出。建议的研究涉及分阶段发展和 实施了SQUID设计，以提高空间分辨率并最大限度地提高 特定的应用程序。将进一步利用现有的专业知识来开发和改进鱿鱼传感器。 适用于需要更高灵敏度的SQUID磁力计和 梯度计，但空间分辨率较低。范德比尔特的一项激进的生物物理测量计划 再加上HYPRES的技术专长，将产生一种具有商业吸引力的UHRSM 在制造新的鱿鱼传感器设计方面，这是一项有价值的国家能力。 演出现场(S)(组织、市、州) HYPRES股份有限公司部门物理学与天文学系 克利尔布鲁克路175号范德比尔特大学 纽约州埃尔姆斯福德，纳什维尔1023，TN 37235 关键人员。请参阅说明。根据需要使用续页，以如下所示的格式提供所需信息。 从首席调查员开始。按字母顺序列出所有其他关键人员，姓氏在前。 命名项目中的组织角色 Masoud HYPRES，Inc.首席调查员Radparvar 弗朗茨·范德比尔特大学的Baudenbacher描述鱿鱼 亨特，Richard HYpres，Inc.鱿鱼制造 Patt，Roy HYPRES，Inc.Squid制造公司 Tolpygo，Sergey HYPRES，Inc.鱿鱼制造公司 披露许可声明。仅适用于SBIR/STTR。请参阅说明。^是FJ否 小灵通398(05/01版)第2页在整个表格第2页底部连续编号 应用程序。不要使用2a、2b等后缀。 首席调查员/项目主任(最后、第一、中间)： 必须在每张打印页和每张续页的顶部提供首席调查员/项目主任的姓名。 研究补助金

DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishmentsand the use of the first person. This abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. The objective of the proposed research is to develop Ultra-High Resolution, thin film low-temperature superconductivity (LTS) SQUID Magnetometers (UHRSM) with integrated pickup-loops and Additional Positive Feedback (APF). The UHRSM will be optimized for imaging of the magnetic fields produced by action currents, injury and developmental currents, remnant magnetization, and magnetic susceptibility in isolated living tissue and small experimental animal preparations. As a collaborative effort between HYPRES and several research institutions, including Living State Physics of Vanderbilt University, analog SQUID magnetometers are being developed for imaging applications. In order to utilize SQUIDs for these applications, their voltages are amplified by a step-up transformer so it could be instrumented with room temperature electronics. The use of a step-up transformer requires extensive peripheral electronics for linearization, thus limiting the number of SQUID magnetometer channels in a practical system. We are proposing to develop a novel SQUID with APF that eliminates the need for the transformer, and as a result simplifies the peripheral electronics significantly. The proposed APF SQUID integrates an on-chip feedback coil with the SQUID. This can increase the gain of the device substantially, and as a result no step-up transformer is required for read out. The proposed research involves the staged development and implementation of a SQUID design to enhance the spatial resolution and maximize the field sensitivity for specific applications. The existing expertise will be exploited further to develop and improve SQUID sensors for general and custom biomagnetic applications which require higher-sensitivity SQUID magnetometers and gradiometers but lower spatial resolution. An aggressive program of biophysical measurements at Vanderbilt coupled with the technical expertise at HYPRES will lead to both a commercially attractive UHRSM instrument and a valuable national capability for fabrication of new designs for SQUID sensors. PERFORMANCE SITE(S) (organization, city, state) HYPRES, Inc. Dept. of Physics and Astronomy 175 Clearbrook Rd. Vanderbilt University Elmsford, NY 1023 Nashville, TN 37235 KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Radparvar, Masoud HYPRES, Inc. Principal Investigator Baudenbacher, Franz Vanderbilt University SQUID Characterization Hunt, Richard HYPRES, Inc. SQUID Fabrication Patt, Roy HYPRES, Inc. SQUID Fabrication Tolpygo, Sergey HYPRES, Inc. SQUID Fabrication Disclosure Permission Statement. Applicable toSBIR/STTR Only. See instructions. ^ Yes FJ No PHS 398 (Rev. 05/01) Page 2 Number pages consecutively atthe bottom throughout Form Page 2 the application. Do not use suffixes such as 2a, 2b. Principal Investigator/ProgramDirector (Last, First, Middle): The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT