HIGH-SPEED DUAL ENERGY DIGITAL SUBTRACTION ANGIOGRAPHY

描述（由申请人提供）： 美国有超过2000个导管插入实验室，每年进行超过100万次冠状动脉导管插入术和同等数量的非冠状动脉导管插入术。科学研究实验室（SRL）提出开发一种改进的数字成像技术，用于可视化对比填充结构，该技术可应用于目前使用对比成像的所有情况下，与现有技术相比具有许多优势。该技术，双能量数字减影血管造影（DEDSA），使用专有的X射线源，依赖于新型阳极涂层和X射线过滤器，以提高对造影剂的灵敏度，同时抑制由于组织和骨骼的功能。该源技术也可应用于双能量对比度增强数字减影乳腺X射线摄影（CEDSM），这是最近才被证明。SRL已经证明了碘造影剂在校准的拟人模型内以及在切除的动物器官内的DEDSA成像。在这个项目中，我们也将证明使用钆造影剂的能力。钆化合物（如Gd-DTPA）提供了许多优于碘的优点，用于DEDSA成像，包括改善的组织消除和较低的患者剂量，目前广泛用作MRI造影剂。该计划的目标是开发和演示一个原型DEDSA X射线源能够用于实时减影成像。该源是基于电子轰击的外来阳极材料，其中之一是在第一阶段高功率证明，其余的将在第二阶段的发展。一旦该源被开发出来，它将被优化并用于使用碘和钆造影剂来展示和完善DEDSA成像。

DESCRIPTION (provided by applicant): There are over 2000 catheterization laboratories in the U.S. performing over 1 million coronary catheterizations and an equivalent number of non-coronary catheterization procedures per year. Science Research Laboratory (SRL) proposes to develop an improved digital imaging technique for visualizing contrast-filled structures that could be applied in all cases where contrast imaging is currently used with many advantages over current techniques. The technique, Dual-Energy Digital-Subtraction Angiography (DEDSA), uses a proprietary x-ray source that relies on novel anode coatings and x-ray filters to enhance the sensitivity to contrast agent while suppressing features due to tissue and bone. The source technology also can be applied to dual-energy contrast enhanced digital subtraction mammography (CEDSM), which has only recently been demonstrated. SRL has demonstrated DEDSA imaging of iodine contrast agent within calibrated anthropomorphic phantoms as well as within excised animal organs. In this program we will demonstrate the capability of using gadolinium contrast agents as well. Gadolinium compounds (such as Gd-DTPA) offer many advantages over iodine for DEDSA imaging, including improved tissue cancellation and lower patient dose, and are currently widely used as MRI contrast agents. The goal of this program is to develop and demonstrate a prototype DEDSA x-ray source capable of being used for real-time subtracted imaging. The source is based on electron bombardment of exotic anode materials, one of which was demonstrated at high power in Phase I, and the rest of which will be developed in Phase II. Once this source is developed it will be optimized and used to demonstrate and perfect DEDSA imaging using iodine and gadolinium contrast agents.