TULANE NATINAL PRIMATE RESEARCH CENTER

超出空间 但前提是。 本申请申请为杜兰国家灵长类动物研究中心(TNPRC)提供五年的资金 2003年5月1日至2008年4月30日。资金将用于支持政府， 该中心的业务、兽医资源和科研资源。要支持的额外资金 还要求开展试点研究项目和与群体健康相关的研究资源项目。 近三年来，TNPRC的研究项目一直专注于传染病研究 几十年。尽管该中心S的大部分研究工作都致力于传染病，但也有 还迅速扩大了基因治疗和辅助生殖技术方面的项目。有传染性的 疾病方案目前的重点是艾滋病、疟疾、微孢子虫病和莱姆病。这些是 涉及TNPRC多个部门的调查人员和合作者的多学科研究 在中心外。这些研究涵盖了从传播、诊断和发病机制到 疫苗策略和化疗方法的发展，从病理损伤到基因 序列。此外，基因治疗计划的发展允许采用新的方法来治疗 多种疾病的治疗和各种基因治疗模式的临床前建模。 在过去的五年里，特别是在过去的一年里，中心发生了重大变化， Peter Gerone博士退休并任命Andrew Lackner博士为新主任。从10月1日开始， 2001年，当拉克纳博士成为主任时，几个部门的领导层发生了变化，新的部门 已经成立，业务办公室(现在的行政事务)已经开始重组。这个 Result是一家现在更重视研究项目的中心，它经历了50%的 其赠款投资组合的增长。这些变化是由一位非常乐于助人的合作者促成的 机构。TNPRC的新组织结构和领导团队以及最近在 获得赠款资金和吸引外部合作表明，中心准备在一段时间内 显著增长和改善。

EXCEED THE SPACE PROVIDED. This application requests funding for the Tulane National Primate Research Center (TNPRC) for the five year period beginning May 1, 2003 through April 30, 2008. Funds will be used to support the administration, operations, veterinary resources, and scientific research resources of the Center. Additional funds to support pilot research projects and colony-health-related research resource projects are also requested. The research program at the TNPRC has been focused on infectious disease research for close to three decades. Although the majority of the Center' s research efforts are devoted to infectious disease, there are also rapidly expanding programs in gene therapy and assisted reproductive technologies. The infectious disease program currently focuses on AIDS, Malaria Microsporidial diseases and Lyme disease. These are multidisciplinary studies involving investigators in- numerous Divisions at the TNPRC and collaborators outside the Center. The studies cover the spectrum from transmission, diagnosis and pathogenesis to development of vaccine strategies and chemotherapeutic treatments, and from pathologic lesions to gene sequences. In addition, the development of the gene therapy program allows for novel approaches to the treatment of many types of disease and preclinical modeling of a variety of gene therapy modalities. The last five years and particularly the last year have seen significant changes at the Center, following the retirement of Dr. Peter Gerone and the naming of Dr. Andrew Lackner as the new Director. Since October 1, 2001 when Dr. Lackner became Director, leadership in several of the divisions has changed, new divisions have been formed and the business office (now Administrative Services) has begun reorganization. The result is a Center that now places more emphasis on research programs and which has experienced a 50% growth in its grant portfolio. These changes have been facilitated by a very helpful and collegial host institution. The new organizational structure and leadership team at the TNPRC and recent successes in obtaining grant funding and attracting outside collaboration suggest that the Center is poised for a period of significant growth and improvement.