beta-3-Peptide Helix Dimers of Defined Orientation

描述（由申请人提供）：《自然》中的折叠聚合物是由相对简单的单体制成的，但它们通过非共价相互作用的网络采用复杂的折叠结构。非天然折叠聚合物（foldamers）也具有类似的多功能性。如果这些分子要充分发挥其作为生物学和医学工具的潜力，那么控制文件夹结构是至关重要的。即使没有循环约束，β -3-多肽也能形成稳定的螺旋结构。研究这种折叠体结构的下一个合乎逻辑的步骤是寻找β -3肽，它们可以采用明确的三级结构，如螺旋束和卷曲的线圈。我们希望利用筛选方法从β -3肽库中鉴定出可以形成平行或反平行螺旋二聚体的肽。这些实验将开始建立β -3肽折叠体的高阶结构形成规则，并为设计更复杂的结构打开大门。

DESCRIPTION (provided by applicant): Folded polymers in Nature are made from relatively simple monomers, but they adopt complex folded structures through networks of non-covalent interactions. Nonnatural folded polymers, or foldamers, have the potential for similar versatility. Control of foldamer structure is crucial if these molecules are to realize their full potential as tools in biology and medicine. beta-3-Peptides have been shown to form stable helices, even without cyclic constraints. The logical next step in the study of such foldamer structures is to search for beta-3-peptides that can adopt well defined tertiary structures, such as helical bundles and coiled coils. We hope to use screening methods to identify peptides that can form parallel or antiparallel helical dimers from a library of beta-3-peptides. These experiments will begin to establish the rules of higher order structure formation of beta-3-peptide foldamers and open the door to designing more complex structures.