BIOINFORMATICS OF 3 PRIME-UTR-BASED POST-TRANSCRIPTIONAL REGULATORY ELEMENTS

描述（由申请人提供）：本提案旨在通过缅因州七家机构之间的生物医学研究卓越网络（INBRE）寻求对缅因州生物医学研究基础设施网络（BRIN）的持续支持，其中荒岛山生物实验室（MDIBL）为牵头机构。INBRE的总体目标是通过进一步发展我们的合作网络来增强和加强缅因州的生物医学研究能力，该合作网络由两家主要研究机构（MDIBL，杰克逊实验室），两家本科和研究生学位授予机构（缅因大学，大西洋学院）和三家本科学位授予机构(贝茨学院，鲍登学院，INBRE将在BRIN建立的成功基础上，通过以比较功能基因组学为主题的多学科研究网络，进一步加强生物医学研究基础设施，并扩大缅因州科学家发展生物医学研究竞争力的机会。研究网络中常见的假设是，脊椎动物模型（包括板骨目、硬骨鱼、鸟类和哺乳动物物种）的同源基因组区域的初级结构的保守性预测了感兴趣的蛋白质中功能域的位置，并确定了潜在的新的调控序列，可以使用这些比较模型在功能分析中进行测试。缅因州的INBRE将a)为初级教师提供研究支持和核心设施；b)为参与机构的本科生创造全年和季节性的研究和培训机会，c)为缅因州所有本科机构和社区学院的学生和教师提供外展活动，并通过上述方式，d)作为本科生追求健康研究事业的管道，增强缅因州劳动力的科学和技术知识。

DESCRIPTION (provided by applicant): This proposal seeks continued support for Maine's Biomedical Research Infrastructure Network (BRIN) through an IdeA Network of Biomedical Research Excellence (INBRE) among seven Maine institutions, with the Mount Desert Island Biological Laboratory (MDIBL) serving as lead institution. The overall goal of this INBRE is to augment and strengthen Maine's biomedical research capacity by further developing our collaborative network composed of two premier research institutions (MDIBL, The Jackson Laboratory), two undergraduate and graduate degree granting institutions (The University of Maine, College of the Atlantic), and three undergraduate degree granting institutions (Bates College, Bowdoin College, Colby College) INBRE will build on the successful foundation established by BRIN by further strengthening biomedical research infrastructure through a multidisciplinary research network with a thematic scientific focus in comparative functional genomics and with expanded opportunities for developing the biomedical research competitiveness of Maine scientists. The common hypothesis within the research network is that conservation of primary structure across orthologous genomic regions of vertebrate models, including elasmobranch, teleost, avian and mammalian species predicts the location of functional domains in proteins of interest, and also identifies potential novel regulatory sequences that can be tested in functional assays using these comparative models Maine's INBRE will a) provide research support and core facilities to junior faculty, postdoctoral fellows and graduate students at participating institutions, b) create year-round and seasonal research and training opportunities for undergraduate students at participating institutions, c) provide outreach activities to students and faculty at all undergraduate institutions and community colleges in Maine, and through the above, d) serve as a pipeline for undergraduate students to pursue health research careers and enhance the scientific and technical knowledge of Maine's work force.