Affymetrix GSC3000 microarray scanner

描述(由申请人提供)：Sidney Kimmel癌症中心是一个非营利性研究机构，成立于1991年，由USPH拨款支持癌症遗传学、细胞生物学、血液学和造血学、免疫学以及血管生物学的研究项目。该中心已迅速发展到23名调查人员和170多名支持人员。Sidney Kimmel癌症中心校园由两座建筑组成，其中一座是最近建造的，包括Torrey Pines Mesa上最后两个未开发的地块。这些地段上的研究设施将于年内动工。 SKCC的基因组核心成立于1995年，目前拥有1.25FTE，提供Q-PCR、液体处理机器人、定制阵列制造和Affymetrix微阵列方面的服务。拟议购买新的Affymetrix微阵列扫描仪和流体站将使Affymetrix服务继续运营，同时将每个基因的阵列成本降低四倍，并通过改进的机器设计提高产量。SKCC已经确定了六个主要用户和22个其他用户，他们的研究计划要么需要这个系统，要么将通过继续获得这项技术而得到显着增强。所有主要用户和许多其他用户都已经使用过这个系统。其中一个亮点包括两个不同的小组，他们使用Affymetrix系统来识别似乎在前列腺癌进展中重要的基因。

DESCRIPTION (provided by applicant): The Sidney Kimmel Cancer Center is a nonprofit research institute founded in 1991 with USPH grant supported research programs in cancer genetics, cell biology, hematology and hematopoiesis and immunology, and vascular biology. The center has grown rapidly to 23 investigators and over 170 support staff. The Sidney Kimmel Cancer Center Campus consists of two buildings, one recently constructed, and includes the last two undeveloped lots on Torrey Pines Mesa. Building of research facilities on these lots will commence within the year. The Genome Core at SKCC was begun in 1995 and currently has 1.25 FTE providing services in Q-PCR, liquid handling robotics, custom array manufacture, and Affymetrix microarrays. The proposed purchase of the new Affymetrix microarray scanner and fluidics station will allow the continued operation of the Affymetrix service, while decreasing the array costs per gene by fourfold, and increasing throughput with improved machine design. Six major and twenty two other users have been identified at SKCC whose research programs either require this system or would be significantly enhanced by continued access to this technology. All of the major users and many of the other users have already used this system. One of the highlights includes two separate groups that have used the Affymetrix system to identify genes that appear to be important in prostate cancer progression.