COBRE: USC: APC AND MITOSIS - LINK WITH CYTOPLASMIC DYNEIN, COLON CANCER

描述(由申请人提供)：这项Cobre提案的主要目标是增加加州活跃的、由NIH资助的生物医学研究人员的数量。这将通过南加州大学的一些研究人员的共同努力来实现，他们已经将他们的集体专业知识融合在一起，组成了一个研究结直肠癌的生物学、其治疗和预防的多学科研究小组。结直肠癌是美国癌症死亡的主要原因，每年约有15万新病例和5.6万人死亡。由于结直肠肿瘤的耐药性，以及这些方案引起的毒副作用，目前的药物治疗方案在管理疾病方面只提供了微乎其微的好处。为这一应用而聚集在一起的生物医学科学家组成了一个跨学科的中心，结肠癌研究中心(CCCR)，该中心专注于结直肠癌问题。在目前的Cobre应用中提出的研究有三个目标。一是开展影响结直肠癌及其治疗的特定分子、生化、遗传和生活方式因素的研究。这将通过支持由有前途的初级教员领导的四个项目来实现。第二个目标是提供支持这些研究项目的核心设施，使牵头调查人员具备必要的最先进的技术能力。最终目标是管理一个项目，通过该项目，四名年轻教师以及五年拨款期间将招聘的十名新教师，由在NIH资金方面有实质性记录的知名调查人员进行指导。总之，本申请中提出的科布雷计划将有两个长期的好处。首先，国家卫生研究院在自然科学领域的竞争性研究人员数量将增加。其次，CCCR将准备申请结肠癌领域的项目拨款。在南加州和其他理想国家，这样的拨款很少。

DESCRIPTION (provided by applicant): The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of SC. This will be accomplished through the combined efforts of a number of investigators at the USC who have merged their collective expertise in formation of a multidisciplinary research group studying the biology of colorectal cancer, its therapy, and its prevention. Colorectal cancer is a leading cause of cancer death in the US, with about 150,000 new cases and 56,000 deaths occurring annually. Current pharmacologic regimens provide only marginal benefit in managing the disease, owing to the drug resistance of colorectal tumors, as well as to the toxic side-effects evoked by these regimens. The biomedical scientists who have come together for this application have formed an interdisciplinary center, the Center for Colon Cancer Research (CCCR) that has focused its efforts around the problem of colorectal cancer. The research proposed in the current COBRE application has three aims. The first is to carry out research on specific molecular, biochemical, genetic, and lifestyle factors that impact upon colorectal cancer and its therapy. This will be done by supporting four projects led by promising junior faculty members. The second aim is to provide core facilities in support of these research projects, giving the lead investigators necessary state-of-the-art technical capabilities. The final aim is to manage a program through which the four young faculty, as well as ten new faculty to be recruited during the five-year period of the grant, are mentored by established investigators with substantive records in NIH funding. In all, the COBRE program proposed in this application will have two long-tern1 benefits. First, the number of NIH-competitive researchers in SC will increase. Second, the CCCR will be poised to apply for a program project grant in the area of colon cancer. Such grants are few in SC and in other IdeA states.