SD COBRE: MYOCYTE POLARITY AND SIGNAL TRANSDUCTION IN MYOCARDIAL INFARCTION

描述(由申请人提供)：这项建议是建立一个生物医学研究卓越中心(COBRE)，主题是“心血管重塑的机制”。心血管疾病占美国所有死亡人数的近一半。近年来，人们普遍认识到心血管系统的病理性重构可能不仅仅是血流动力学紊乱的结果，而是可能在疾病过程中发挥主要作用。预防或逆转头部、血管和肾脏重塑的治疗干预显然可以降低死亡率和提高生活质量。相关的神经体液和分子/信号机制还知之甚少。意识到这一领域的发现具有巨大的治疗意义，南达科他大学医学院已有意识地努力组建一支研究团队，专注于心血管重塑方面的工作。最近招聘了四名在这一领域有研究兴趣的有前途的新教师。每一位都接受了世界知名的调查人员的培训。科布雷主任是国际公认的心血管重塑专家。NIH资助的另外两名具有心血管专业知识的教师将提供额外的指导和技术援助。总体而言，该团队拥有生理学、药理学、形态学、分子生物学、信号转导、转基因、基因组学和蛋白质组学方面的专业知识。科博尔基金将帮助我们有前途的初级科学家开发出多产的产品。NIH资助的研究计划，并将增加深度和更多的专业知识，为该团队。我们相信，最终的结果将是一个国际公认的研究项目，为该领域做出实质性贡献。科布雷包括四个项目和四个核心(包括行政管理)。由王学军博士领导的项目1将确定泛素-蛋白酶体系统在衰竭心脏重构中的致病作用。由李发千博士领导的项目2将测试一个关键信号通路在细胞生长中的作用，该信号通路导致心力衰竭时心腔扩张。由Rachid Kacimi博士领导的项目3将研究新发现的细胞因子在缺血性心力衰竭中的作用。

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence; (COBRE) on "Mechanisms of Cardiovascular Remodeling". Cardiovascular diseases account for nearly half of all deaths in the US. In recent years, it has become widely recognized that pathological remodeling of the cardiovascular system may not be simply a consequence of hemodynamic derangements but may play a primary role in the disease process. Therapeutic interventions that prevent or reverse remodeling in the head, blood vessels, and kidneys clearly lead to a reduction in mortality and improvement in quality of life. The associated neurohumoral and molecular/signaling mechanisms are poor y understood. Realizing the enormous therapeutic implications of discoveries in this field, the University of South Dakota School of Medicine has made a conscious effort to assemble a team of investigators to focus on work in cardiovascular remodeling. Four promising new faculty with research interests in this area have been recruited recently. Each have trained with world-renowned investigators. The COBRE Director is an internationally recognized expert in cardiovascular remodeling. Two other NIH funded faculty with cardiovascular expertise will provide additional mentoring and technical assistance. Cumulatively, the group has expertise in physiology, pharmacology, morphology, molecular biology, signal transduction, transgenesis, genomics, and proteomics. COBRE funding will facilitate our promising junior scientists in developing productive. NIH-funded research programs and will add depth and additional expertise to the croup. We believe the end result will be an internationally recognized research program that makes substantial contributions to the field. The COBRE contains four projects and four cores (including administration). Project 1, led by Dr. Xuejun Wang, will define the pathogenic role of the ubiquitin-proteasome system in cardiac remodeling in failure. Project 2, led by Dr. Faqian Li, will test the role of a key signaling pathway in cell growth leading to chamber dilatation in heart failure. Project 3, led by Dr. Rachid Kacimi, will examine the role of newly discovered cytokines in ischemic heart failure.