MT COBRE: EFFECT OF METAL MIXTURES ON GENE EXPRESSION & CARCINOGENESIS

描述(由申请人提供)：CEHS成立于2000年，目标是开发一个具有全国竞争力的研究计划，研究人类疾病的机制和环境对人类疾病的影响。为了实现这一目标，选择了三个重点研究领域，以便根据国家的需要和现有教职人员的专门知识，在每个领域培养足够数量的调查人员。这些重点领域是呼吸/免疫毒理学、神经毒理学以及遗传和心血管毒理学。在初创公司的支持下，该公司聘请了五名有才华的新教师，第六名正在招聘中。建立了最先进的核心设施，并实施了强有力的指导计划。Cobre的这项申请非常适合发展新的教员，聘请更多的教员来进一步加强现有的教员，并加强支持网络和基础设施，将CEHS发展成为一个具有全国竞争力的中心。 本申请的具体目标是： 目标1通过单项子项目的支持促进六大人才队伍的发展 目标2通过战略招聘四名新教员，提高密歇根大学具有竞争力的CEHS调查人员的临界质量。 目标3为CEHS调查人员建立一个支持网络，以促进基础设施发展、协作互动和促进指导。 目的4通过为共用ICPMS和流式细胞仪购置急需的仪器，加强CEHS研究的基础设施；并改进设施，即ICPMS洁净室、组织培养、小动物手术以及生物信息学和计算核心设施。 我们建议，随着这些具体目标的实现，所有由科布雷基金支持的研究人员将转移到R01基金，并创造一个整体研究环境，以便CEHS调查人员将能够获得NIEHS中心拨款、NIEHS提供的博士培训拨款和项目项目拨款支持。

DESCRIPTION (provided by applicant): The CEHS was established in 2000 with the goal of developing a nationally competitive research program to study the mechanism of human disease and environmental impacts on human disease. In order to achieve this goal three focus areas of research were selected in order to facilitate the development of a critical mass of investigators in each area and on the basis of national need and expertise within the existing faculty. These focus areas are respiratory/immunotoxicology, neurotoxicology, and genetic and cardiovascular toxicology. With the aid of startup support five talented new faculty were hired and a sixth is being recruited. State-of-the-art core facilities were established and a strong mentoring program was put into place. This COBRE application is an ideal fit to develop the new faculty, hire additional faculty to further enhance the existing faculty and to enhance the support network and the infrastructure to develop the CEHS to a nationally competitive center. The specific aims of this application are: Aim 1 Promote the development of six talented faculty through the support of individual sub-projects Aim 2 Enhance the critical mass of competitive CEHS investigators at the UM through strategic recruitment of four new faculty. Aim 3 Establish a support network for CEHS investigators that promotes infrastructure development, collaborative interaction and facilitate mentoring. Aim 4 Enhance the infrastructure for CEHS research through the acquisition of critically needed instrumentation for a shared ICPMS and Flow Cytometer; and improve facilities, i.e., clean room for ICPMS, tissue culture, small animal surgery and a bioinformatics and computational core facility. We propose that with the achievement of these specific aims that all of the investigators supported by this COBRE grant will move into R01 funding and that the an overall research environment will have been created so that the CEHS investigators will be able to obtain a NIEHS center grant, a Ph.D. training grant from the NIEHS and program project grant support.