MT COBRE: CONSEQUENCES OF AHR-MEDIATED SIGNALING IN DENDRITIC CELLS

描述（由申请人提供）：CEHS成立于2000年，目标是发展一个具有全国竞争力的研究项目，研究人类疾病的机制和环境对人类疾病的影响。为了实现这一目标，选择了三个重点研究领域，以便根据国家需要和现有教师的专业知识，促进在每个领域培养临界数量的研究人员。这些重点领域是呼吸/免疫毒理学、神经毒理学、遗传和心血管毒理学。在创业支持的帮助下，五名有才华的新教师被聘用，第六名正在招聘中。建立了最先进的核心设施，并实施了强有力的指导计划。这个COBRE应用程序非常适合发展新的教师队伍，雇佣更多的教师来进一步加强现有的教师队伍，加强支持网络和基础设施，将CEHS发展成为一个具有全国竞争力的中心。

DESCRIPTION (provided by applicant): The CEHS was established in 2000 with the goal of developing a nationally competitive research program to study the mechanism of human disease and environmental impacts on human disease. In order to achieve this goal three focus areas of research were selected in order to facilitate the development of a critical mass of investigators in each area and on the basis of national need and expertise within the existing faculty. These focus areas are respiratory/immunotoxicology, neurotoxicology, and genetic and cardiovascular toxicology. With the aid of startup support five talented new faculty were hired and a sixth is being recruited. State-of-the-art core facilities were established and a strong mentoring program was put into place. This COBRE application is an ideal fit to develop the new faculty, hire additional faculty to further enhance the existing faculty and to enhance the support network and the infrastructure to develop the CEHS to a nationally competitive center. The specific aims of this application are: Aim 1 Promote the development of six talented faculty through the support of individual sub-projects Aim 2 Enhance the critical mass of competitive CEHS investigators at the UM through strategic recruitment of four new faculty. Aim 3 Establish a support network for CEHS investigators that promotes infrastructure development, collaborative interaction and facilitate mentoring. Aim 4 Enhance the infrastructure for CEHS research through the acquisition of critically needed instrumentation for a shared ICPMS and Flow Cytometer; and improve facilities, i.e., clean room for ICPMS, tissue culture, small animal surgery and a bioinformatics and computational core facility. We propose that with the achievement of these specific aims that all of the investigators supported by this COBRE grant will move into R01 funding and that the an overall research environment will have been created so that the CEHS investigators will be able to obtain a NIEHS center grant, a Ph.D. training grant from the NIEHS and program project grant support.