Generating endogenous antigen specific T regulatory cells to treat autoimmune MPO-ANCA GN

肾小球肾炎(GN)是一种影响肾脏滤过器官(肾小球)的炎症性疾病。最严重和最具侵袭性的形式是ANCA相关的GN，其原因是对髓过氧化物酶(MPO)失去耐受性。目前的治疗方法是有毒的。这项研究将开发新的策略来恢复对MPO的免疫耐受，从而治疗这种疾病。我们将使用动物模型来提供概念证明，即这些新的疗法可以治疗MPO-ANCA相关性肾炎。

Glomerulonephritis (GN) is an inflammatory disease that affects the filtering organs (glomeruli) of the kidney. The most severe and aggressive form is ANCA-associated GN resulting from loss of tolerance to myeloperoxidase (MPO). Current therapies are toxic. This study will develop new strategies to restore immune tolerance to MPO thus treating patients with this disease. We will use an animal model to provide proof-of-concept that these novel therapies can treat MPO-ANCA associated GN.