Novel immunomodulatory therapeutic strategies to target intracellular pathogens

这是一个在LSTM治疗学和药物发现领域工作的令人兴奋的机会。您将被整合到一个非常活跃的研究小组，拥有多样化的研究组合。项目将致力于确定针对关键细胞内病原体（结核分枝杆菌、淋病尼瑟菌、肠沙门氏菌）的新治疗策略。项目将利用离体人体感染模型、先进的分析技术（共聚焦显微镜和流式细胞术）和药效学-药代动力学（PK-PD）模型来研究发病机制、耐药性的出现，并评估新疗法的临床可治疗性。项目将为候选人量身定制，并提供行业培训和海外实习机会。

This is an exciting opportunity to work in the area of therapeutics and drug discovery at LSTM. You will be integrated into an extremely active research group with a diverse research portfolio. Projects will work towards the identification of novel therapeutic strategies targeting key intracellular pathogens (Mycobacterium tuberculosis, Nisseria gonorrhoeae, Salmonella enterica). Projects will utilise ex vivo human models of infection, advanced analytical techniques (confocal microscopy and flow cytometry), and pharmacodynamic-pharmacokinetic (PK-PD) modelling to study pathogenesis, resistance emergence, and to assess the clinical tractability of novel therapeutics. Projects will be tailored to the candidate and provide opportunity for industry training and overseas placement.