New Opportunities in Enantioselective Catalysis Using Lewis Acidic Boranes

主基团化学是近20年来经历了复兴的一个热门研究领域。这可以部分归因于主基团化合物所表现出的独特的化学性质和反应活性，可以为过渡金属催化提供补充。此外，全球面临着越来越大的挑战，即开发催化方法，为社会生产化学品，为基于贵金属的催化剂提供替代品。因此，该博士研究生的中心目标是开发使用主基团催化剂的新方法，使其反应性多样化，这是一个重要而及时的追求。为此，一系列具有挑战性的对映选择性转化采用刘易斯酸性硼烷将被开发。该计划将通过立体选择性合成方法的发展显著推进主基团催化。一个高度积极和专注的学生将获得合成有机化学/主基团催化方面的全面培训，并将获得一个高度刺激的项目，这将塑造这个令人兴奋的新研究项目的未来。该领域的主管最近发表的出版物包括Org。科学通报，2016,22(2):444 - 444。欧元。[J] .化学学报，2022,28,e202202454。Soc。Rev., 2021, 50,3720, ACS catalal。中文信息学报，2020,10,4835；化学。Int。编辑，2018,57,12356，ACS。， 2017, 7, 7748。该学生将由阿斯利康化学开发团队的一名成员共同监督，并将在博士课程期间在阿斯利康现场度过3个月。

Main group chemistry is a topical area of research that has undergone a renaissance in the past 20 years. This can partly be attributed to the unique chemistry and reactivity exhibited by main group compounds, which can offer complementarity to transition metal catalysis. Furthermore, there is an increasing global challenge to develop catalytic methods to produce chemicals for society that provide alternatives to catalysts based on precious metals. As such, the central goal of this PhD studentship is the development of novel methodologies that employ main group catalysts, diversifying their reactivity profile, which is an important and timely pursuit. To this end, a collection of challenging enantioselective transformations employing Lewis acidic boranes will been developed. This program will significantly advance main group catalysis through the development of stereoselective synthetic methods. A highly motivated and dedicated student will gain a thorough training in synthetic organic chemistry / main group catalysis, and be rewarded with a highly stimulating project that will shape the future of this exciting new research program. Recent publications from the supervisors in this area include Org. Lett. 2022, 24, 8694, Chem. Eur. J., 2022, 28, e202202454, Chem. Soc. Rev., 2021, 50, 3720, ACS Catal., 2020, 10, 4835, Angew. Chem. Int. Ed., 2018, 57, 12356, ACS Catal., 2017, 7, 7748.The student will be co-supervised by a member of the Chemical Development team at AstraZeneca, and will spend 3-months on site at AstraZeneca during the course of the PhD.